USDOE Joint Genome Institute (JGI), Berkeley, CA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
National University of Life & Environmental Sciences, Kyiv (Ukraine)
LF Lambert Spawn Co., Coatesville, PA (United States)
National Academy of Sciences, Kyiv (Ukraine)
Univ. of Warsaw (Poland)
Univ. of Florida, Gainesville, FL (United States)
Leibniz Institute for Natural Product Research & Infection Biology, Jena (Germany)
Univ. of Toronto, ON (Canada); University of Toronto Scarborough, Toronto (Canada)
National Univ. of Singapore (Singapore)
Cornell Univ., Ithaca, NY (United States)
Duke University School of Medicine, Durham, NC (United States)
Duke Univ., Durham, NC (United States)
Michigan State Univ., East Lansing, MI (United States)
Univ. of Michigan, Ann Arbor, MI (United States)
USDOE Joint Genome Institute (JGI), Berkeley, CA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); Univ. of California, Berkeley, CA (United States)
Oregon State Univ., Corvallis, OR (United States)
Univ. of California, Riverside, CA (United States)
The first genome sequenced of a eukaryotic organism was for Saccharomyces cerevisiae, as reported in 1996, but it was more than 10 years before any of the zygomycete fungi, which are the early-diverging terrestrial fungi currently placed in the phyla Mucoromycota and Zoopagomycota, were sequenced. The genome for Rhizopus delemar was completed in 2008; currently, more than 1000 zygomycete genomes have been sequenced. Genomic data from these early-diverging terrestrial fungi revealed deep phylogenetic separation of the two major clades—primarily plant—associated saprotrophic and mycorrhizal Mucoromycota versus the primarily mycoparasitic or animal-associated parasites and commensals in the Zoopagomycota. Genomic studies provide many valuable insights into how these fungi evolved in response to the challenges of living on land, including adaptations to sensing light and gravity, development of hyphal growth, and co-existence with the first terrestrial plants. Genome sequence data have facilitated studies of genome architecture, including a history of genome duplications and horizontal gene transfer events, distribution and organization of mating type loci, rDNA genes and transposable elements, methylation processes, and genes useful for various industrial applications. Pathogenicity genes and specialized secondary metabolites have also been detected in soil saprobes and pathogenic fungi. Novel endosymbiotic bacteria and viruses have been discovered during several zygomycete genome projects. Overall, genomic information has helped to resolve a plethora of research questions, from the placement of zygomycetes on the evolutionary tree of life and in natural ecosystems, to the applied biotechnological and medical questions.
Gryganskyi, Andrii P., et al. "Sequencing the Genomes of the First Terrestrial Fungal Lineages: What Have We Learned?." Microorganisms, vol. 11, no. 7, Jul. 2023. https://doi.org/10.3390/microorganisms11071830
Gryganskyi, Andrii P., Golan, Jacob, Muszewska, Anna, Idnurm, Alexander, Dolatabadi, Somayeh, Mondo, Stephen J., Kutovenko, Vira B., Kutovenko, Volodymyr O., Gajdeczka, Michael T., Anishchenko, Iryna M., Pawlowska, Julia, Tran, Ngoc Vinh, Ebersberger, Ingo, Voigt, Kerstin, Wang, Yan, Chang, Ying, Pawlowska, Teresa E., Heitman, Joseph, ... Stajich, Jason E. (2023). Sequencing the Genomes of the First Terrestrial Fungal Lineages: What Have We Learned?. Microorganisms, 11(7). https://doi.org/10.3390/microorganisms11071830
Gryganskyi, Andrii P., Golan, Jacob, Muszewska, Anna, et al., "Sequencing the Genomes of the First Terrestrial Fungal Lineages: What Have We Learned?," Microorganisms 11, no. 7 (2023), https://doi.org/10.3390/microorganisms11071830
@article{osti_2242458,
author = {Gryganskyi, Andrii P. and Golan, Jacob and Muszewska, Anna and Idnurm, Alexander and Dolatabadi, Somayeh and Mondo, Stephen J. and Kutovenko, Vira B. and Kutovenko, Volodymyr O. and Gajdeczka, Michael T. and Anishchenko, Iryna M. and others},
title = {Sequencing the Genomes of the First Terrestrial Fungal Lineages: What Have We Learned?},
annote = {The first genome sequenced of a eukaryotic organism was for Saccharomyces cerevisiae, as reported in 1996, but it was more than 10 years before any of the zygomycete fungi, which are the early-diverging terrestrial fungi currently placed in the phyla Mucoromycota and Zoopagomycota, were sequenced. The genome for Rhizopus delemar was completed in 2008; currently, more than 1000 zygomycete genomes have been sequenced. Genomic data from these early-diverging terrestrial fungi revealed deep phylogenetic separation of the two major clades—primarily plant—associated saprotrophic and mycorrhizal Mucoromycota versus the primarily mycoparasitic or animal-associated parasites and commensals in the Zoopagomycota. Genomic studies provide many valuable insights into how these fungi evolved in response to the challenges of living on land, including adaptations to sensing light and gravity, development of hyphal growth, and co-existence with the first terrestrial plants. Genome sequence data have facilitated studies of genome architecture, including a history of genome duplications and horizontal gene transfer events, distribution and organization of mating type loci, rDNA genes and transposable elements, methylation processes, and genes useful for various industrial applications. Pathogenicity genes and specialized secondary metabolites have also been detected in soil saprobes and pathogenic fungi. Novel endosymbiotic bacteria and viruses have been discovered during several zygomycete genome projects. Overall, genomic information has helped to resolve a plethora of research questions, from the placement of zygomycetes on the evolutionary tree of life and in natural ecosystems, to the applied biotechnological and medical questions.},
doi = {10.3390/microorganisms11071830},
url = {https://www.osti.gov/biblio/2242458},
journal = {Microorganisms},
issn = {ISSN 2076-2607},
number = {7},
volume = {11},
place = {United States},
publisher = {MDPI},
year = {2023},
month = {07}}