Homeostatic regulation of meiotic DSB formation by ATM/ATR

Journal Article · Sat Nov 15 04:00:00 EST 2014 · Experimental Cell Research

DOI:https://doi.org/10.1016/J.YEXCR.2014.07.016· OSTI ID:22416958

Cooper, Tim J.; Wardell, Kayleigh; Garcia, Valerie

Ataxia–telangiectasia mutated (ATM) and RAD3-related (ATR) are widely known as being central players in the mitotic DNA damage response (DDR), mounting responses to DNA double-strand breaks (DSBs) and single-stranded DNA (ssDNA) respectively. The DDR signalling cascade couples cell cycle control to damage-sensing and repair processes in order to prevent untimely cell cycle progression while damage still persists [1]. Both ATM/ATR are, however, also emerging as essential factors in the process of meiosis; a specialised cell cycle programme responsible for the formation of haploid gametes via two sequential nuclear divisions. Central to achieving accurate meiotic chromosome segregation is the introduction of numerous DSBs spread across the genome by the evolutionarily conserved enzyme, Spo11. This review seeks to explore and address how cells utilise ATM/ATR pathways to regulate Spo11-DSB formation, establish DSB homeostasis and ensure meiosis is completed unperturbed.

• OSTI ID: 22416958
• Journal Information: Experimental Cell Research, Journal Name: Experimental Cell Research Journal Issue: 1 Vol. 329; ISSN 0014-4827; ISSN ECREAL
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
BIOLOGICAL REPAIR
CELL CYCLE
CHROMOSOMES
DNA
ENZYMES
GAMETES
HOMEOSTASIS
MEIOSIS
STRAND BREAKS