Towards integration of PET/MR hybrid imaging into radiation therapy treatment planning

Journal Article · Tue Jul 15 04:00:00 EDT 2014 · Medical Physics

DOI:https://doi.org/10.1118/1.4881317· OSTI ID:22412471

Thorwath, Daniela ^[1]; Schmidt, Holger ^[2]; Quick, Harald H. ^[3]

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1. Section for Biomedical Physics, University Hospital for Radiation Oncology, Eberhard Karls University Tübingen, Tübingen 72076 (Germany)
2. Department of Diagnostic and Interventional Radiology, Eberhard Karls University Tübingen, Tübingen 72076 (Germany)
3. Institute of Medical Physics, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen 91052 (Germany)

Purpose: Multimodality imaging has become an important adjunct of state-of-the-art radiation therapy (RT) treatment planning. Recently, simultaneous PET/MR hybrid imaging has become clinically available and may also contribute to target volume delineation and biological individualization in RT planning. For integration of PET/MR hybrid imaging into RT treatment planning, compatible dedicated RT devices are required for accurate patient positioning. In this study, prototype RT positioning devices intended for PET/MR hybrid imaging are introduced and tested toward PET/MR compatibility and image quality. Methods: A prototype flat RT table overlay and two radiofrequency (RF) coil holders that each fix one flexible body matrix RF coil for RT head/neck imaging have been evaluated within this study. MR image quality with the RT head setup was compared to the actual PET/MR setup with a dedicated head RF coil. PET photon attenuation and CT-based attenuation correction (AC) of the hardware components has been quantitatively evaluated by phantom scans. Clinical application of the new RT setup in PET/MR imaging was evaluated in anin vivo study. Results: The RT table overlay and RF coil holders are fully PET/MR compatible. MR phantom and volunteer imaging with the RT head setup revealed high image quality, comparable to images acquired with the dedicated PET/MR head RF coil, albeit with 25% reduced SNR. Repositioning accuracy of the RF coil holders was below 1 mm. PET photon attenuation of the RT table overlay was calculated to be 3.8% and 13.8% for the RF coil holders. With CT-based AC of the devices, the underestimation error was reduced to 0.6% and 0.8%, respectively. Comparable results were found within the patient study. Conclusions: The newly designed RT devices for hybrid PET/MR imaging are PET and MR compatible. The mechanically rigid design and the reproducible positioning allow for straightforward CT-based AC. The systematic evaluation within this study provides the technical basis for the clinical integration of PET/MR hybrid imaging into RT treatment planning.

• OSTI ID: 22412471
• Journal Information: Medical Physics, Journal Name: Medical Physics Journal Issue: 7 Vol. 41; ISSN 0094-2405; ISSN MPHYA6
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ACCURACY
COMPARATIVE EVALUATIONS
HEAD
IMAGE PROCESSING
NECK
NMR IMAGING
PATIENTS
PHANTOMS
RADIOTHERAPY