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Title: Cell culture arrays using micron-sized ferromagnetic ring-shaped thin films

Abstract

Cell patterning has become an important technology for tissue engineering. In this research, domain walls are formed at the two ends of a ferromagnetic ring thin film after applying a strong external magnetic field, which can effectively attract magnetically labeled cells and control the position for biological cell. Magnetophoresis experiment was conducted to quantify the magnetic nanoparticle inside the cells. A ring-shaped magnetic thin films array was fabricated through photolithography. It is observed that magnetically labeled cells can be successfully attracted to the two ends of the ring-shaped magnetic thin film structure and more cells were attracted and further attached to the structures. The cells are co-cultured with the structure and kept proliferating; therefore, such ring thin film can be an important candidate for in-vitro biomedical chips or tissue engineering.

Authors:
;  [1]; ;  [2]
  1. Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu City 300, Taiwan (China)
  2. Institute of NanoEngineering and MicroSystems, National Tsing Hua University, Hsinchu City 300, Taiwan (China)
Publication Date:
OSTI Identifier:
22409949
Resource Type:
Journal Article
Journal Name:
Journal of Applied Physics
Additional Journal Information:
Journal Volume: 117; Journal Issue: 17; Other Information: (c) 2015 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0021-8979
Country of Publication:
United States
Language:
English
Subject:
75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY; 60 APPLIED LIFE SCIENCES; ANIMAL TISSUES; CELL CULTURES; FERROMAGNETIC MATERIALS; FERROMAGNETISM; IN VITRO; MAGNETIC FIELDS; THIN FILMS

Citation Formats

Huang, Chen-Yu, Wei, Zung-Hang, E-mail: wei@pme.nthu.edu.tw, Lai, Mei-Feng, and Ger, Tzong-Rong. Cell culture arrays using micron-sized ferromagnetic ring-shaped thin films. United States: N. p., 2015. Web. doi:10.1063/1.4913816.
Huang, Chen-Yu, Wei, Zung-Hang, E-mail: wei@pme.nthu.edu.tw, Lai, Mei-Feng, & Ger, Tzong-Rong. Cell culture arrays using micron-sized ferromagnetic ring-shaped thin films. United States. doi:10.1063/1.4913816.
Huang, Chen-Yu, Wei, Zung-Hang, E-mail: wei@pme.nthu.edu.tw, Lai, Mei-Feng, and Ger, Tzong-Rong. Thu . "Cell culture arrays using micron-sized ferromagnetic ring-shaped thin films". United States. doi:10.1063/1.4913816.
@article{osti_22409949,
title = {Cell culture arrays using micron-sized ferromagnetic ring-shaped thin films},
author = {Huang, Chen-Yu and Wei, Zung-Hang, E-mail: wei@pme.nthu.edu.tw and Lai, Mei-Feng and Ger, Tzong-Rong},
abstractNote = {Cell patterning has become an important technology for tissue engineering. In this research, domain walls are formed at the two ends of a ferromagnetic ring thin film after applying a strong external magnetic field, which can effectively attract magnetically labeled cells and control the position for biological cell. Magnetophoresis experiment was conducted to quantify the magnetic nanoparticle inside the cells. A ring-shaped magnetic thin films array was fabricated through photolithography. It is observed that magnetically labeled cells can be successfully attracted to the two ends of the ring-shaped magnetic thin film structure and more cells were attracted and further attached to the structures. The cells are co-cultured with the structure and kept proliferating; therefore, such ring thin film can be an important candidate for in-vitro biomedical chips or tissue engineering.},
doi = {10.1063/1.4913816},
journal = {Journal of Applied Physics},
issn = {0021-8979},
number = 17,
volume = 117,
place = {United States},
year = {2015},
month = {5}
}