Retrospective evaluation of dosimetric quality for prostate carcinomas treated with 3D conformal, intensity modulated and volumetric modulated arc radiotherapy

Journal Article · Sun Dec 15 04:00:00 EST 2013 · Journal of Medical Radiation Sciences (Print)

DOI:https://doi.org/10.1002/JMRS.24· OSTI ID:22402334

Crowe, Scott B ^[1]; Kairn, Tanya ^[1]; Middlebrook, Nigel; Hill, Brendan; Christie, David R H; Knight, Richard T ^[2]; Kenny, John ^[3]; Langton, Christian M; Trapp, Jamie V ^[1]

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1. Science and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland (Australia)
2. Premion, Wesley Medical Centre, Brisbane, Queensland (Australia)
3. Australian Clinical Dosimetry Services, Australian Radiation Protection and Nuclear Safety Agency, Melbourne, Victoria (Australia)

This study examines and compares the dosimetric quality of radiotherapy treatment plans for prostate carcinoma across a cohort of 163 patients treated across five centres: 83 treated with three-dimensional conformal radiotherapy (3DCRT), 33 treated with intensity modulated radiotherapy (IMRT) and 47 treated with volumetric modulated arc therapy (VMAT). Treatment plan quality was evaluated in terms of target dose homogeneity and organs at risk (OAR), through the use of a set of dose metrics. These included the mean, maximum and minimum doses; the homogeneity and conformity indices for the target volumes; and a selection of dose coverage values that were relevant to each OAR. Statistical significance was evaluated using two-tailed Welch's T-tests. The Monte Carlo DICOM ToolKit software was adapted to permit the evaluation of dose metrics from DICOM data exported from a commercial radiotherapy treatment planning system. The 3DCRT treatment plans offered greater planning target volume dose homogeneity than the other two treatment modalities. The IMRT and VMAT plans offered greater dose reduction in the OAR: with increased compliance with recommended OAR dose constraints, compared to conventional 3DCRT treatments. When compared to each other, IMRT and VMAT did not provide significantly different treatment plan quality for like-sized tumour volumes. This study indicates that IMRT and VMAT have provided similar dosimetric quality, which is superior to the dosimetric quality achieved with 3DCRT.

• OSTI ID: 22402334
• Journal Information: Journal of Medical Radiation Sciences (Print), Journal Name: Journal of Medical Radiation Sciences (Print) Journal Issue: 4 Vol. 60; ISSN 2051-3895
• Country of Publication: Australia
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
COMPLIANCE
DATA
DOSES
HAZARDS
LICENSES
PATIENTS
PLANNING
PROSTATE
RADIOTHERAPY
REDUCTION