Synthesis and characterization of polylactide/doxorubicin/magnetic nanoparticles composites for drug delivery

Journal Article · Fri May 22 04:00:00 EDT 2015 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.4918443· OSTI ID:22391859

Mhlanga, Nikiwe; Ray, Suprakas Sinha ^[1]

---

1. Department of Applied Chemistry, University of Johannesburg, Doornforntein, 2028, Johannesburg (South Africa)

Magnetic iron oxide nanoparticles have potential to transform conventional therapeutics, through targeted delivery by external magnetic field modulation. Conventional drug delivery lacks specificity; both normal and infected cells are exposed to toxic drugs. Consequently, the toxicity towards healthy cells leads to detrimental side effects which are formidable. However, iron oxide research in biomedicine has been hindered by their lack of stability. This study reports on the stabilization of iron oxide by polylactide (PLA). Besides affording stable iron oxide, PLA is also good for sustained delivery of the drug. PLA/doxorubicin/magnetic nanoparticles (PLA/DOX/MNPs) spheres were synthesized by solvent evaporation method and DOX anticancer drug was encapsulated. The spheres were characterized using scanning electron microscope, Fourier transform infrared microscope, thermogravimetric analyzer and UV-visible spectroscopy, which ascertained formation of the anticipated spheres and incorporation of DOX. In vitro drug release studies were carried out in both phosphate buffer (pH 7.4) and acetate buffer (pH 4.6) and they showed the same trend in both mediums. Drug release kinetics followed Higuchi model, which proved drug release by diffusion via a diffusion gradient.

• OSTI ID: 22391859
• Journal Information: AIP Conference Proceedings, Journal Name: AIP Conference Proceedings Journal Issue: 1 Vol. 1664; ISSN APCPCS; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
71 CLASSICAL AND QUANTUM MECHANICS
GENERAL PHYSICS
ABSORPTION SPECTROSCOPY
ACETATES
COMPOSITE MATERIALS
DIFFUSION
DOXORUBICIN
EVAPORATION
FOURIER TRANSFORMATION
IRON OXIDES
MAGNETIC FIELDS
MANGANESE PHOSPHIDES
NANOPARTICLES
PH VALUE
PHOSPHATES
SCANNING ELECTRON MICROSCOPY
SYNTHESIS
THERMAL GRAVIMETRIC ANALYSIS