Preclinical assessment of dopaminergic system in rats by MicroPET using three positron-emitting radiopharmaceuticals

Journal Article · Fri Nov 07 00:00:00 EST 2014 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.4901363· OSTI ID:22390525

Lara-Camacho, V. M., E-mail: [e-mail]; Ávila-García, M. C., E-mail: [e-mail]; Ávila-Rodríguez, M. A., E-mail: [e-mail] ^[1]

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1. Unidad PET, Facultad de Medicina, Universidad Nacional Autónoma de México, 04510, México, D.F. (Mexico)

Different diseases associated with dysfunction of dopaminergic system such as Parkinson, Alzheimer, and Schizophrenia are being widely studied with positron emission tomography (PET) which is a noninvasive method useful to assess the stage of these illnesses. In our facility we have recently implemented the production of [{sup 11}C]-DTBZ, [{sup 11}C]-RAC, and [{sup 18}F]-FDOPA, which are among the most common PET radiopharmaceuticals used in neurology applications to get information about the dopamine pathways. In this study two healthy rats were imaged with each of those radiotracers in order to confirm selective striatum uptake as a proof of principle before to release them for human use.

• OSTI ID: 22390525
• Journal Information: AIP Conference Proceedings, Vol. 1626, Issue 1; Conference: 13. Mexican Symposium on Medical Physics, Leon, Guanajuato (Mexico), 15-16 Mar 2014; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
CARBON 11
DOPAMINE
FLUORINE 18
NERVOUS SYSTEM DISEASES
NEUROLOGY
POSITRON COMPUTED TOMOGRAPHY
RADIOPHARMACEUTICALS
RATS
TRACER TECHNIQUES
UPTAKE