Tissue distribution of co-planar and non-planar tetra- and hexa-chlorobiphenyl isomers in guinea pigs after oral ingestion
- Public Health Institute, Ljubljana (Slovenia)
- Univ. of Ljubljana (Slovenia)
Food ingestion is the most important route for the uptake of lipophilic organochlorine contaminants. Uptake and transfer of the contaminants from the digestive tract to target organs can be used for risk evaluation. The bioconcentration and migration of polychlorobiphenyls (PCBs) is highly structure - dependent. Bioconcentration is correlated with lipophilicity on the basis of the n-octanol/water partition coefficient in its logarithmic form - logKow. However, some factors e.g. diffusion through cell membranes, accumulation in specific organs and tissues, uptake and deputation kinetics and metabolism can also influence the bioconcentration. Individual PCB compounds of commercial PCB preparation are taken up by organisms to markedly different extents. Until now little is known about the distribution of non-planar and co-planar PCBs in different tissues. Co-planar PCBs have dioxin - like toxicity. This study examines differences in the bioconcentration of two pairs of tetra and hexa chlorobiphenyls from the digestive tract and their distribution in different tissues of guinea pigs.
- OSTI ID:
- 223897
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology, Vol. 56, Issue 3; Other Information: PBD: Mar 1996
- Country of Publication:
- United States
- Language:
- English
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