Structure of human dual-specificity phosphatase 27 at 2.38 Å resolution
The X-ray crystal structure of human dual-specificity phosphatase 27 (DUSP27) is reported at 2.38 Å resolution. There are over 100 genes in the human genome that encode protein tyrosine phosphatases (PTPs) and approximately 60 of these are classified as dual-specificity phosphatases (DUSPs). Although many dual-specificity phosphatases are still not well characterized, novel functions have been discovered for some of them that have led to new insights into a variety of biological processes and the molecular basis for certain diseases. Indeed, as the functions of DUSPs continue to be elucidated, a growing number of them are emerging as potential therapeutic targets for diseases such as cancer, diabetes and inflammatory disorders. Here, the overexpression, purification and structure determination of DUSP27 at 2.38 Å resolution are presented.
- OSTI ID:
- 22351229
- Journal Information:
- Acta Crystallographica. Section D: Biological Crystallography, Vol. 67, Issue Pt 5; Other Information: PMCID: PMC3087626; PMID: 21543850; PUBLISHER-ID: dz5226; OAI: oai:pubmedcentral.nih.gov:3087626; Copyright (c) International Union of Crystallography 2011; Country of input: International Atomic Energy Agency (IAEA); ISSN 0907-4449
- Country of Publication:
- Denmark
- Language:
- English
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