Outcome after Radiofrequency Ablation of Sarcoma Lung Metastases

Journal Article · Sat Feb 15 04:00:00 EST 2014 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-013-0644-9· OSTI ID:22318116

Koelblinger, Claus ^[1]; Strauss, Sandra ^[2]; Gillams, Alice ^[3]

---

1. KH Barmherzige Schwestern Ried, Department of Radiology (Austria)
2. UCL and UCLH, Department of Medical Oncology (United Kingdom)
3. The London Clinic, Department of Radiology (United Kingdom)

Purpose: Resection is the mainstay of management in patients with sarcoma lung metastases, but there is a limit to how many resections can be performed. Some patients with inoperable disease have small-volume lung metastases that are amenable to thermal ablation. We report our results after radiofrequency ablation (RFA). Methods: This is a retrospective study of patients treated from 2007 to 2012 in whom the intention was to treat all sites of disease and who had a minimum CT follow-up of 4 months. Treatment was performed under general anesthesia/conscious sedation using cool-tip RFA. Follow-up CT scans were analyzed for local control. Primary tumor type, location, grade, disease-free interval, prior resection/chemotherapy, number and size of lung tumors, uni- or bilateral disease, complications, and overall and progression-free survival were recorded. Results: Twenty-two patients [15 women; median age 48 (range 10–78) years] with 55 lung metastases were treated in 30 sessions. Mean and median tumor size and initial number were 0.9 cm and 0.7 (range 0.5–2) cm, and 2.5 and 1 (1–7) respectively. Median CT and clinical follow-up were 12 (4–54) and 20 (8–63) months, respectively. Primary local control rate was 52 of 55 (95 %). There were 2 of 30 (6.6 %) Common Terminology Criteria grade 3 complications with no long-term sequelae. Mean (median not reached) and 2- and 3-year overall survival were 51 months, and 94 and 85 %. Median and 1- and 2-year progression-free survival were 12 months, and 53 and 23 %. Prior disease-free interval was the only significant factor to affect overall survival. Conclusion: RFA is a safe and effective treatment for patients with small-volume sarcoma metastases.

• OSTI ID: 22318116
• Journal Information: Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 1 Vol. 37; ISSN 0174-1551; ISSN CAIRDG
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ABLATION
ANESTHESIA
CAT SCANNING
CHEMOTHERAPY
CONTROL
LUNGS
MANAGEMENT
METASTASES
PATIENTS
RADIOWAVE RADIATION
SARCOMAS
WHO
WOMEN