Comparative analysis of 11 different radioisotopes for palliative treatment of bone metastases by computational methods

Journal Article · Sat Nov 01 00:00:00 EDT 2014 · Medical Physics

DOI:https://doi.org/10.1118/1.4897240· OSTI ID:22317964

Guerra Liberal, Francisco D. C., E-mail: [e-mail], E-mail: [e-mail]; Tavares, Adriana Alexandre S., E-mail: [e-mail], E-mail: [e-mail]; Tavares, João Manuel R. S., E-mail: [e-mail] ^[1]

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1. Instituto de Engenharia Mecânica e Gestão Industrial, Faculdade de Engenharia, Universidade do Porto, Rua Dr. Roberto Frias s/n, Porto 4200-465 (Portugal)

Purpose: Throughout the years, the palliative treatment of bone metastases using bone seeking radiotracers has been part of the therapeutic resources used in oncology, but the choice of which bone seeking agent to use is not consensual across sites and limited data are available comparing the characteristics of each radioisotope. Computational simulation is a simple and practical method to study and to compare a variety of radioisotopes for different medical applications, including the palliative treatment of bone metastases. This study aims to evaluate and compare 11 different radioisotopes currently in use or under research for the palliative treatment of bone metastases using computational methods. Methods: Computational models were used to estimate the percentage of deoxyribonucleic acid (DNA) damage (fast Monte Carlo damage algorithm), the probability of correct DNA repair (Monte Carlo excision repair algorithm), and the radiation-induced cellular effects (virtual cell radiobiology algorithm) post-irradiation with selected particles emitted by phosphorus-32 ({sup 32}P), strontium-89 ({sup 89}Sr), yttrium-90 ({sup 90}Y ), tin-117 ({sup 117m}Sn), samarium-153 ({sup 153}Sm), holmium-166 ({sup 166}Ho), thulium-170 ({sup 170}Tm), lutetium-177 ({sup 177}Lu), rhenium-186 ({sup 186}Re), rhenium-188 ({sup 188}Re), and radium-223 ({sup 223}Ra). Results: {sup 223}Ra alpha particles, {sup 177}Lu beta minus particles, and {sup 170}Tm beta minus particles induced the highest cell death of all investigated particles and radioisotopes. The cell survival fraction measured post-irradiation with beta minus particles emitted by {sup 89}Sr and {sup 153}Sm, two of the most frequently used radionuclides in the palliative treatment of bone metastases in clinical routine practice, was higher than {sup 177}Lu beta minus particles and {sup 223}Ra alpha particles. Conclusions: {sup 223}Ra and {sup 177}Lu hold the highest potential for palliative treatment of bone metastases of all radioisotopes compared in this study. Data reported here may prompt future in vitro and in vivo experiments comparing different radionuclides for palliative treatment of bone metastases, raise the need for the careful rethinking of the current widespread clinical use of {sup 89}Sr and {sup 153}Sm, and perhaps strengthen the use of {sup 223}Ra and {sup 177}Lu in the palliative treatment of bone metastases.

• OSTI ID: 22317964
• Journal Information: Medical Physics, Vol. 41, Issue 11; Other Information: (c) 2014 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-2405
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ALGORITHMS
ALPHA PARTICLES
APOPTOSIS
COMPARATIVE EVALUATIONS
CURRENTS
DNA
DNA DAMAGES
EMISSION
EXCISION REPAIR
HOLMIUM 166
IN VITRO
IN VIVO
IRRADIATION
LUTETIUM 177
METASTASES
MONTE CARLO METHOD
PARTICLES
PHOSPHORUS 32
RADIOBIOLOGY
RADIUM 223
RHENIUM 186
RHENIUM 188
SAMARIUM 153
SIMULATION
SKELETON
STRONTIUM 89
SURVIVAL CURVES
THULIUM 170
TIN 117
TRACER TECHNIQUES
YTTRIUM 90