In vitro cytotoxicity tests of ZnO‐Bi{sub 2}O{sub 3}‐Mn{sub 2}O{sub 3}-based varistor fabricated from ZnO micro and nanoparticle powders on L929 mouse cells

Journal Article · Fri Oct 24 04:00:00 EDT 2014 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.4898539· OSTI ID:22308085

Mahmud, Shahrom; Munshi, Ayman ^[1]; Seeni, Azman ^[2]

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1. Nano-optoelectronics Research and Technology Laboratory (N.O.R.), School of Physics, Universiti Sains Malaysia, 11800, Penang (Malaysia)
2. Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, 13200, Bertam, Pulau Pinang (Malaysia)

The present study investigated the cytotoxicity of ZnO‐Bi{sub 2}O{sub 3}‐Mn{sub 2}O{sub 3}-varistors. To this effect, ZnO‐Bi{sub 2}O{sub 3}‐Mn{sub 2}O{sub 3} varistors fabricated from ZnO micro-and nanoparticle powders are prepared via conventional ceramic processing method. The effects of ZnO particle size on the properties of ZnO varistors are also investigated. The strong solid-state reaction during sintering may be attributed to the high surface area of the 20 nm ZnO nanoparticles that promote strong surface reaction. The intensity of XRD peaks reflected the high degree of crystallinity of the ZnO nanoparticles. However, the width of the peaks in case of ZnO nanoparticles has increased due to the quantum size effect. The cytotoxicity evaluation of ZnO varistor was conducted on mouse connective tissue fibroblast cells (L929) using Trypan Blue Exclusion Assay analysis. The results show that the four types of varistor samples lead to cellular mitochondrial dysfunction, morphological modifications and apoptosis at the various concentration range and the toxic effects are obviously displayed in high concentration samples. 20nm-VDR is the most toxic materials followed by 40nm-VDR, P8-VDR, and W4-VDR in a descending order.

• OSTI ID: 22308085
• Journal Information: AIP Conference Proceedings, Journal Name: AIP Conference Proceedings Journal Issue: 1 Vol. 1621; ISSN APCPCS; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

36 MATERIALS SCIENCE
60 APPLIED LIFE SCIENCES
APOPTOSIS
BISMUTH OXIDES
CERAMICS
CONCENTRATION RATIO
CONNECTIVE TISSUE
FIBROBLASTS
IN VITRO
MANGANESE OXIDES
MICE
MITOCHONDRIA
NANOPARTICLES
PARTICLE SIZE
SEMICONDUCTOR RESISTORS
SINTERING
SURFACE AREA
TOXIC MATERIALS
TOXICITY
TRYPAN BLUE
X-RAY DIFFRACTION
ZINC OXIDES