Mechanisms of Biomolecular Self-Assembly Investigated Through In Situ Observations of Structures and Dynamics

Schmid, Sakshi Yadav; Lachowski, Kacper; Chiang, Huat Thart; Pozzo, Lilo; De Yoreo, Jim; Zhang, Shuai

doi:10.1002/ange.202309725

Mechanisms of Biomolecular Self-Assembly Investigated Through In Situ Observations of Structures and Dynamics

Journal Article · Wed Sep 13 00:00:00 EDT 2023 · Angewandte Chemie

DOI:https://doi.org/10.1002/ange.202309725· OSTI ID:2228252

^[1]; ^[2]; ^[2]; ^[2]; De Yoreo, Jim ^[3]; Zhang, Shuai ^[3]

Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
University of Washington, Seattle, WA (United States)
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); University of Washington, Seattle, WA (United States)

Biomolecular self-assembly of hierarchical materials is a precise and adaptable bottom-up approach to synthesizing across scales with considerable energy, health, environment, sustainability, and information technology applications. To achieve desired functions in biomaterials, it is essential to directly observe assembly dynamics and structural evolutions that reflect the underlying energy landscape and the assembly mechanism. This report will summarize the current understanding of biomolecular assembly mechanisms based on in situ characterization and discuss the broader significance and achievements of newly gained insights. In addition, we will also introduce how emerging deep learning/machine learning-based approaches, multiparametric characterization, and high-throughput methods can boost the development of biomolecular self-assembly. The objective of this review is to accelerate the development of in situ characterization approaches for biomolecular self-assembly and to inspire the next generation of biomimetic materials.

View Accepted Manuscript (DOE)

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division (MSE)

Grant/Contract Number:: AC05-76RL01830; SC0019288

OSTI ID:: 2228252

Alternate ID(s):: OSTI ID: 1999946

Report Number(s):: PNNL-SA-181358

Journal Information:: Angewandte Chemie, Journal Name: Angewandte Chemie Journal Issue: 48 Vol. 135; ISSN 0044-8249

Publisher:: German Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Mechanisms of Biomolecular Self–Assembly Investigated Through In Situ Observations of Structures and Dynamics

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Mechanisms of Biomolecular Self-Assembly Investigated Through In Situ Observations of Structures and Dynamics

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