Engineering of gadofluoroprobes: Broad-spectrum applications from cancer diagnosis to therapy

Journal Article · Mon Jan 13 00:00:00 EST 2014 · Applied Physics Letters

DOI:https://doi.org/10.1063/1.4861881· OSTI ID:22275768

Sharma, Prashant K. ^[1]; Tiwari, Vandana ^[2]; Tiwari, Vivek; Patel, Anant B. ^[3]; Pandey, Ravindra ^[4]; Pandey, Avinash C. ^[1]

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1. Nanotechnology Application Centre, University of Allahabad, Allahabad 211002 (India)
2. Department of Pathology, KGMU, Lucknow (India)
3. Centre for Cellular and Molecular Biology, Hyderabad (India)
4. Department of Physics, Michigan Technological University, Michigan 49931-1295 (United States)

The engineering of the Gadolinium based nanostructures have been demonstrated in this paper. Nanostructures of α-Gd{sub 2}S{sub 3} exhibit a unique transition between ferromagnetic state and paramagnetic state of the system. It was demonstrated that their properties could be tuned for a wide range of applications ranging from hyperthermia to Magnetic Resonance Imaging, owing to their magnetic moments and large relaxivities. Metallic Gd nanoparticles obtained by reduction method were employed for cancer imaging in mice. The Gd nanoparticles were coated with Curcumin and their biomedical implications in the field of simultaneous diagnosis and therapy of cancer and related diseases has been discussed.

• OSTI ID: 22275768
• Journal Information: Applied Physics Letters, Vol. 104, Issue 2; Other Information: (c) 2014 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); ISSN 0003-6951
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
75 CONDENSED MATTER PHYSICS
SUPERCONDUCTIVITY AND SUPERFLUIDITY
77 NANOSCIENCE AND NANOTECHNOLOGY
BIOMEDICAL RADIOGRAPHY
CURCUMIN
GADOLINIUM
GADOLINIUM SULFIDES
MAGNETIC MOMENTS
NANOSTRUCTURES
NEOPLASMS