Study of polyvinyl alcohol nanofibrous membrane by electrospinning as a magnetic nanoparticle delivery approach
- Institute of NanoEngineering and MicroSystems, National Tsing Hua University, Hsinchu, Taiwan (China)
- Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan (China)
- Department of Applied Physics, National Ping Tung University of Education, Pingtung, Taiwan (China)
- Center of Nanoscience and Nanotechnology, National Chung Hsing University, Taichung, Taiwan (China)
Electrospinning technique was used to fabricate polyvinyl alcohol (PVA)-based magnetic biodegradable nanofibers. PVA solution was mixed with ferrofluid or magnetic nanoparticles (MNPs) powder and formed two individual nanofibrous membranes (PVA/ferrofluid and PVA/MNPs powder) by electrospinning. The surface morphology of the nanofibrous membrane was characterized by scanning electron microscopy and the magnetic properties were measured by vibrating sample magnetometer. Macrophages (RAW 264.7) were co-cultured with the nanofibrous membranes for 12, 24, and 48 h and exhibited good cell viability (>95%). Results showed that the PVA fibers would be degraded and the embedded Fe{sub 3}O{sub 4} nanoparticles would be released and delivered to cells.
- OSTI ID:
- 22273722
- Journal Information:
- Journal of Applied Physics, Journal Name: Journal of Applied Physics Journal Issue: 17 Vol. 115; ISSN JAPIAU; ISSN 0021-8979
- Country of Publication:
- United States
- Language:
- English
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