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Title: Naphthazarin protects against glutamate-induced neuronal death via activation of the Nrf2/ARE pathway

Abstract

Highlights: •Naphthazarin activates the Nrf2/ARE pathway. •Naphthazarin induces Nrf2-driven genes in neurons and astrocytes. •Naphthazarin protects neurons against excitotoxicity. -- Abstract: Nuclear factor E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway is an important cellular stress response pathway involved in neuroprotection. We previously screened several natural phytochemicals and identified plumbagin as a novel activator of the Nrf2/ARE pathway that can protect neurons against ischemic injury. Here we extended our studies to natural and synthetic derivatives of plumbagin. We found that 5,8-dimethoxy-1,4-naphthoquinone (naphthazarin) is a potent activator of the Nrf2/ARE pathway, up-regulates the expression of Nrf2-driven genes in primary neuronal and glial cultures, and protects neurons against glutamate-induced excitotoxicity.

Authors:
; ; ;  [1];  [1];  [2];  [1]
  1. Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, 251 Bayview Blvd., Baltimore, MD 21224 (United States)
  2. (United States)
Publication Date:
OSTI Identifier:
22239555
Resource Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 433; Journal Issue: 4; Other Information: Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANTIOXIDANTS; DEATH; GENES; HEME; NAD; NERVE CELLS; OXYGEN; QUININE

Citation Formats

Son, Tae Gen, Kawamoto, Elisa M., Yu, Qian-Sheng, Greig, Nigel H., Mattson, Mark P., Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, and Camandola, Simonetta, E-mail: camandolasi@mail.nih.gov. Naphthazarin protects against glutamate-induced neuronal death via activation of the Nrf2/ARE pathway. United States: N. p., 2013. Web. doi:10.1016/J.BBRC.2013.03.041.
Son, Tae Gen, Kawamoto, Elisa M., Yu, Qian-Sheng, Greig, Nigel H., Mattson, Mark P., Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, & Camandola, Simonetta, E-mail: camandolasi@mail.nih.gov. Naphthazarin protects against glutamate-induced neuronal death via activation of the Nrf2/ARE pathway. United States. doi:10.1016/J.BBRC.2013.03.041.
Son, Tae Gen, Kawamoto, Elisa M., Yu, Qian-Sheng, Greig, Nigel H., Mattson, Mark P., Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, and Camandola, Simonetta, E-mail: camandolasi@mail.nih.gov. Fri . "Naphthazarin protects against glutamate-induced neuronal death via activation of the Nrf2/ARE pathway". United States. doi:10.1016/J.BBRC.2013.03.041.
@article{osti_22239555,
title = {Naphthazarin protects against glutamate-induced neuronal death via activation of the Nrf2/ARE pathway},
author = {Son, Tae Gen and Kawamoto, Elisa M. and Yu, Qian-Sheng and Greig, Nigel H. and Mattson, Mark P. and Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD and Camandola, Simonetta, E-mail: camandolasi@mail.nih.gov},
abstractNote = {Highlights: •Naphthazarin activates the Nrf2/ARE pathway. •Naphthazarin induces Nrf2-driven genes in neurons and astrocytes. •Naphthazarin protects neurons against excitotoxicity. -- Abstract: Nuclear factor E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway is an important cellular stress response pathway involved in neuroprotection. We previously screened several natural phytochemicals and identified plumbagin as a novel activator of the Nrf2/ARE pathway that can protect neurons against ischemic injury. Here we extended our studies to natural and synthetic derivatives of plumbagin. We found that 5,8-dimethoxy-1,4-naphthoquinone (naphthazarin) is a potent activator of the Nrf2/ARE pathway, up-regulates the expression of Nrf2-driven genes in primary neuronal and glial cultures, and protects neurons against glutamate-induced excitotoxicity.},
doi = {10.1016/J.BBRC.2013.03.041},
journal = {Biochemical and Biophysical Research Communications},
number = 4,
volume = 433,
place = {United States},
year = {Fri Apr 19 00:00:00 EDT 2013},
month = {Fri Apr 19 00:00:00 EDT 2013}
}