Stereotactic Ablative Body Radiation Therapy for Octogenarians With Non-Small Cell Lung Cancer

Journal Article · Sat Jun 01 04:00:00 EDT 2013 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2013.01.006· OSTI ID:22224469

Takeda, Atsuya; Sanuki, Naoko; Eriguchi, Takahisa ^[1]; Kaneko, Takeshi ^[2]; Morita, Satoshi ^[3]; Handa, Hiroshi ^[2]; Aoki, Yousuke; Oku, Yohei ^[1]; Kunieda, Etsuo ^[4]

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1. Radiation Oncology Center, Ofuna Chuo Hospital, Kanagawa (Japan)
2. Respiratory Disease Center, Yokohama City University Medical Center, Kanagawa (Japan)
3. Department of Biostatistics and Epidemiology, Graduate School of Medicine, Yokohama City University, Kanagawa (Japan)
4. Department of Radiation Oncology, Tokai University, Kanagawa (Japan)

Purpose: To retrospectively investigate treatment outcomes of stereotactic ablative body radiation therapy (SABR) for octogenarians with non-small cell lung cancer (NSCLC). Methods and Materials: Between 2005 and 2012, 109 patients aged ≥80 years with T1-2N0M0 NSCLC were treated with SABR: 47 patients had histology-unproven lung cancer; 62 patients had pathologically proven NSCLC. The prescribed doses were either 50 Gy/5 fractions for peripheral tumors or 40 Gy/5 fractions for centrally located tumors. The treatment outcomes, toxicities, and the correlating factors for overall survival (OS) were evaluated. Results: The median follow-up duration after SABR was 24.2 (range, 3.0-64.6) months. Only limited toxicities were observed, except for 1 grade 5 radiation pneumonitis. The 3-year local, regional, and distant metastasis-free survival rates were 82.3%, 90.1%, and 76.8%, respectively. The OS and lung cancer-specific survival rates were 53.7% and 70.8%, respectively. Multivariate analysis revealed that medically inoperable, low body mass index, high T stage, and high C-reactive protein were the predictors for short OS. The OS for the operable octogenarians was significantly better than that for inoperable (P<.01). Conclusions: Stereotactic ablative body radiation therapy for octogenarians was feasible, with excellent OS. Multivariate analysis revealed that operability was one of the predictors for OS. For medically operable octogenarians with early-stage NSCLC, SABR should be prospectively compared with resection.

• OSTI ID: 22224469
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 2 Vol. 86; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
GLOBULINS
HISTOLOGY
IMMUNITY
LUNGS
METASTASES
MULTIVARIATE ANALYSIS
NEOPLASMS
PATIENTS
PNEUMONITIS
RADIATION DOSES
RADIOTHERAPY
TOXICITY