Antifungal activity of gold nanoparticles prepared by solvothermal method

Journal Article · Tue Jan 15 04:00:00 EST 2013 · Materials Research Bulletin

DOI:https://doi.org/10.1016/J.MATERRESBULL.2012.09.069· OSTI ID:22215764

Ahmad, Tokeer ^[1]; Wani, Irshad A.; Lone, Irfan H.; Ganguly, Aparna ^[1]; Manzoor, Nikhat; Ahmad, Aijaz ^[2]; Ahmed, Jahangeer ^[3]; Al-Shihri, Ayed S. ^[4]

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1. Nanochemistry Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi 110025 (India)
2. Department of Biosciences, Jamia Millia Islamia, New Delhi 110025 (India)
3. Department of Chemistry, Michigan State University, East Lansing, MI 48824 (United States)
4. Department of Chemistry, Faculty of Science, King Khalid University, Abha 61413, P.O. Box 9004 (Saudi Arabia)

Graphical abstract: Gold nanoparticles (7 and 15 nm) of very high surface area (329 and 269 m{sup 2}/g) have been successfully synthesized through solvothermal method by using tin chloride and sodium borohydride as reducing agents. As-prepared gold nanoparticles shows very excellent antifungal activity against Candida isolates and activity increases with decrease in the particle size. Display Omitted Highlights: ► Effect of reducing agents on the morphology of gold nanoparticles. ► Highly uniform and monodisperse gold nanoparticles (7 nm). ► Highest surface area of gold nanoparticles (329 m{sup 2/}g). ► Excellent antifungal activity of gold nanoparticles against Candida strains. -- Abstract: Gold nanoparticles have been successfully synthesized by solvothermal method using SnCl{sub 2} and NaBH{sub 4} as reducing agents. X-ray diffraction studies show highly crystalline and monophasic nature of the gold nanoparticles with face centred cubic structure. The transmission electron microscopic studies show the formation of nearly spherical gold nanoparticles of average size of 15 nm using SnCl{sub 2}, however, NaBH{sub 4} produced highly uniform, monodispersed and spherical gold nanoparticles of average grain size of 7 nm. A high surface area of 329 m{sup 2}/g for 7 nm and 269 m{sup 2}/g for 15 nm gold nanoparticles was observed. UV–vis studies assert the excitations over the visible region due to transverse and longitudinal surface plasmon modes. The gold nanoparticles exhibit excellent size dependant antifungal activity and greater biocidal action against Candida isolates for 7 nm sized gold nanoparticles restricting the transmembrane H{sup +} efflux of the Candida species than 15 nm sized gold nanoparticles.

• OSTI ID: 22215764
• Journal Information: Materials Research Bulletin, Journal Name: Materials Research Bulletin Journal Issue: 1 Vol. 48; ISSN MRBUAC; ISSN 0025-5408
• Country of Publication: United States
• Language: English

Related Subjects

36 MATERIALS SCIENCE
77 NANOSCIENCE AND NANOTECHNOLOGY
ELECTRON MICROSCOPY
ELECTRONS
FCC LATTICES
GOLD
GRAIN SIZE
NANOSTRUCTURES
OPTICAL PROPERTIES
PARTICLE SIZE
PARTICLES
REDUCING AGENTS
SURFACE AREA
SURFACES
SYNTHESIS
TIN CHLORIDES
X-RAY DIFFRACTION