Muscle mitochondrial metabolism and calcium signaling impairment in patients treated with statins

Journal Article · Thu Mar 01 00:00:00 EST 2012 · Toxicology and Applied Pharmacology

DOI:https://doi.org/10.1016/J.TAAP.2012.01.008· OSTI ID:22215262

CHRU Montpellier, 34295 Montpellier ^[1]; Fabre, O.; Bordenave, S. ^[2]; CHRU Montpellier, 34295 Montpellier ^[1]; Hillaire-Buys, D. ^[3]; Raynaud De Mauverger, E.; Lacampagne, A.; Mercier, J. ^[2]; CHRU Montpellier, 34295 Montpellier ^[1]

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1. France
2. U1046, INSERM, Université Montpellier 1 and Université Montpellier 2, 34295 Montpellier (France)
3. CHRU Montpellier, 34295 Montpellier (France)

The most common and problematic side effect of statins is myopathy. To date, the patho-physiological mechanisms of statin myotoxicity are still not clearly understood. In previous studies, we showed that acute application in vitro of simvastatin caused impairment of mitochondrial function and dysfunction of calcium homeostasis in human and rat healthy muscle samples. We thus evaluated in the present study, mitochondrial function and calcium signaling in muscles of patients treated with statins, who present or not muscle symptoms, by oxygraphy and recording of calcium sparks, respectively. Patients treated with statins showed impairment of mitochondrial respiration that involved mainly the complex I of the respiratory chain and altered frequency and amplitude of calcium sparks. The muscle problems observed in statin-treated patients appear thus to be related to impairment of mitochondrial function and muscle calcium homeostasis, confirming the results we previously reported in vitro. -- Highlights: ► The most common and problematic side effect of statins is myopathy. ► Patients treated with statins showed impairment of mitochondrial respiration. ► Statins-treated patients showed altered frequency and amplitude of calcium sparks.

• OSTI ID: 22215262
• Journal Information: Toxicology and Applied Pharmacology, Vol. 259, Issue 2; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0041-008X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
CALCIUM
CREATINE
HEART
LIPOPROTEINS
MITOCHONDRIA
MUSCLES
PAIN
PATIENTS
RATS
RESPIRATION
SARCOPLASMIC RETICULUM