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Title: Bex2 regulates cell proliferation and apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase pathway

Abstract

Highlights: Black-Right-Pointing-Pointer The expression levels of Bex2 markedly increased in glioma tissues. Black-Right-Pointing-Pointer Bex2 over-expression promoted cell proliferation, while its down-regulation inhibited cell growth. Black-Right-Pointing-Pointer Bex2 down-regulation promoted cell apoptosis via JNK/c-Jun signaling pathway. -- Abstract: The function of Bex2, a member of the Brain Expressed X-linked gene family, in glioma is controversial and its mechanism is largely unknown. We report here that Bex2 regulates cell proliferation and apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase (JNK) pathway. The expression level of Bex2 is markedly increased in glioma tissues. We observed that Bex2 over-expression promotes cell proliferation, while down-regulation of Bex2 inhibits cell growth. Furthermore, Bex2 down-regulation promotes cell apoptosis and activates the JNK pathway; these effects were abolished by administration of the JNK specific inhibitor, (SP600125). Thus, Bex2 may be an important player during the development of glioma.

Authors:
 [1];  [2];  [2];  [1];  [2]; ;  [3];  [1];  [2];  [2];  [3];  [1];  [2];  [2]
  1. Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu (China)
  2. (China)
  3. The Graduate School, Xuzhou Medical College, Xuzhou, Jiangsu (China)
Publication Date:
OSTI Identifier:
22210306
Resource Type:
Journal Article
Journal Name:
Biochemical and Biophysical Research Communications
Additional Journal Information:
Journal Volume: 427; Journal Issue: 3; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0006-291X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; APOPTOSIS; BRAIN; CELL PROLIFERATION; GENES; GLIOMAS

Citation Formats

Zhou, Xiuping, E-mail: xpzhou@xzmc.edu.cn, Lab of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu, Key Laboratory of Brain Disease Biology, Affiliated Hospital of Xuzhou Medical College, Jiangsu, Meng, Qingming, The Graduate School, Xuzhou Medical College, Xuzhou, Jiangsu, Xu, Xuebin, Zhi, Tongle, Shi, Qiong, Lab of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu, Key Laboratory of Brain Disease Biology, Affiliated Hospital of Xuzhou Medical College, Jiangsu, Wang, Yong, Yu, Rutong, E-mail: yu.rutong@163.com, Lab of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu, and Key Laboratory of Brain Disease Biology, Affiliated Hospital of Xuzhou Medical College, Jiangsu. Bex2 regulates cell proliferation and apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase pathway. United States: N. p., 2012. Web. doi:10.1016/J.BBRC.2012.09.100.
Zhou, Xiuping, E-mail: xpzhou@xzmc.edu.cn, Lab of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu, Key Laboratory of Brain Disease Biology, Affiliated Hospital of Xuzhou Medical College, Jiangsu, Meng, Qingming, The Graduate School, Xuzhou Medical College, Xuzhou, Jiangsu, Xu, Xuebin, Zhi, Tongle, Shi, Qiong, Lab of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu, Key Laboratory of Brain Disease Biology, Affiliated Hospital of Xuzhou Medical College, Jiangsu, Wang, Yong, Yu, Rutong, E-mail: yu.rutong@163.com, Lab of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu, & Key Laboratory of Brain Disease Biology, Affiliated Hospital of Xuzhou Medical College, Jiangsu. Bex2 regulates cell proliferation and apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase pathway. United States. doi:10.1016/J.BBRC.2012.09.100.
Zhou, Xiuping, E-mail: xpzhou@xzmc.edu.cn, Lab of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu, Key Laboratory of Brain Disease Biology, Affiliated Hospital of Xuzhou Medical College, Jiangsu, Meng, Qingming, The Graduate School, Xuzhou Medical College, Xuzhou, Jiangsu, Xu, Xuebin, Zhi, Tongle, Shi, Qiong, Lab of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu, Key Laboratory of Brain Disease Biology, Affiliated Hospital of Xuzhou Medical College, Jiangsu, Wang, Yong, Yu, Rutong, E-mail: yu.rutong@163.com, Lab of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu, and Key Laboratory of Brain Disease Biology, Affiliated Hospital of Xuzhou Medical College, Jiangsu. Fri . "Bex2 regulates cell proliferation and apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase pathway". United States. doi:10.1016/J.BBRC.2012.09.100.
@article{osti_22210306,
title = {Bex2 regulates cell proliferation and apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase pathway},
author = {Zhou, Xiuping, E-mail: xpzhou@xzmc.edu.cn and Lab of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu and Key Laboratory of Brain Disease Biology, Affiliated Hospital of Xuzhou Medical College, Jiangsu and Meng, Qingming and The Graduate School, Xuzhou Medical College, Xuzhou, Jiangsu and Xu, Xuebin and Zhi, Tongle and Shi, Qiong and Lab of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu and Key Laboratory of Brain Disease Biology, Affiliated Hospital of Xuzhou Medical College, Jiangsu and Wang, Yong and Yu, Rutong, E-mail: yu.rutong@163.com and Lab of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu and Key Laboratory of Brain Disease Biology, Affiliated Hospital of Xuzhou Medical College, Jiangsu},
abstractNote = {Highlights: Black-Right-Pointing-Pointer The expression levels of Bex2 markedly increased in glioma tissues. Black-Right-Pointing-Pointer Bex2 over-expression promoted cell proliferation, while its down-regulation inhibited cell growth. Black-Right-Pointing-Pointer Bex2 down-regulation promoted cell apoptosis via JNK/c-Jun signaling pathway. -- Abstract: The function of Bex2, a member of the Brain Expressed X-linked gene family, in glioma is controversial and its mechanism is largely unknown. We report here that Bex2 regulates cell proliferation and apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase (JNK) pathway. The expression level of Bex2 is markedly increased in glioma tissues. We observed that Bex2 over-expression promotes cell proliferation, while down-regulation of Bex2 inhibits cell growth. Furthermore, Bex2 down-regulation promotes cell apoptosis and activates the JNK pathway; these effects were abolished by administration of the JNK specific inhibitor, (SP600125). Thus, Bex2 may be an important player during the development of glioma.},
doi = {10.1016/J.BBRC.2012.09.100},
journal = {Biochemical and Biophysical Research Communications},
issn = {0006-291X},
number = 3,
volume = 427,
place = {United States},
year = {2012},
month = {10}
}