MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2

Journal Article · Fri Feb 12 00:00:00 EST 2010 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2009.12.182· OSTI ID:22202369

Wu, Qiong; Jin, Haifeng; Yang, Zhiping; Luo, Guanhong; Lu, Yuanyuan; Li, Kai; Ren, Gui; Su, Tao; Pan, Yan; Feng, Bin; Xue, Zengfu ^[1]; Wang, Xin ^[1]; Fan, Daiming ^[1]

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1. State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 15 Changle Western Road, Xi'an, Shaanxi 710032 (China)

Accumulating evidence suggests small non-coding RNAs (microRNAs) play important roles in human cancer progression. In the present study, we found miR-150 was overexpressed in gastric cancer cell lines and tissues. Ectopic expression of miR-150 promoted tumorigenesis and proliferation of gastric cancer cells. Luciferase reporter assay demonstrated that EGR2 was a direct target of miR-150. Collectively, our study demonstrated that overexpression of miR-150 in gastric cancer could promote proliferation and growth of cancer cells at least partially through directly targeting the tumor-suppressor EGR2, suggesting a potential strategy for the development of miRNA-based treatment of gastric cancer.

• OSTI ID: 22202369
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 392, Issue 3; Other Information: Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ANIMAL TISSUES
CELL PROLIFERATION
GENES
HUMAN POPULATIONS
LUCIFERASE
NEOPLASMS
RNA