Essential role of STIM1 in the development of cardiomyocyte hypertrophy

Journal Article · Fri Nov 06 04:00:00 EST 2009 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2009.08.117· OSTI ID:22199867

Ohba, Takayoshi ^[1]; Watanabe, Hiroyuki ^[2]; Murakami, Manabu ^[1]; Sato, Takako ^[2]; Ono, Kyoichi ^[1]; Ito, Hiroshi ^[2]

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1. Department of Physiology, Akita University Graduate School of Medicine, Akita (Japan)
2. Department of Internal Medicine Division of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, Akita (Japan)

Store-operated Ca{sup 2+} entry (SOCE) through transient receptor potential (TRP) channels is important in the development of cardiac hypertrophy. Recently, stromal interaction molecule 1 (STIM1) was identified as a key regulator of SOCE. In this study, we examined whether STIM1 is involved in the development of cardiomyocyte hypertrophy. RT-PCR showed that cultured rat cardiomyocytes constitutively expressed STIM1. Endothelin-1 (ET-1) treatment for 48 h enhanced TRPC1 expression, SOCE, and nuclear factor of activated T cells activation without upregulating STIM1. However, the knockdown of STIM1 suppressed these effects, thereby preventing a hypertrophic response. These results suggest that STIM1 plays an essential role in the development of cardiomyocyte hypertrophy.

• OSTI ID: 22199867
• Journal Information: Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 1 Vol. 389; ISSN 0006-291X; ISSN BBRCA9
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
CALCIUM IONS
HYPERTROPHY
MOLECULES
POLYMERASE CHAIN REACTION
RATS
RECEPTORS