Feasibility Study of Glass Dosimeter for In Vivo Measurement: Dosimetric Characterization and Clinical Application in Proton Beams

Journal Article · Mon Oct 01 04:00:00 EDT 2012 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2012.03.054· OSTI ID:22149547

Rah, Jeong-Eun; Oh, Do Hoon; Kim, Jong Won ^[1]; Kim, Dae-Hyun; Suh, Tae-Suk ^[2]; Ji, Young Hoon ^[3]; Shin, Dongho; Lee, Se Byeong; Kim, Dae Yong ^[4]

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1. Department of Radiation Oncology, Myongji Hospital, Kwandong University College of Medicine, Goyang (Korea, Republic of)
2. Department of Biomedical Engineering, Catholic University of Korea, Seoul (Korea, Republic of)
3. Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)
4. Proton Therapy Center, National Cancer Center, Goyang (Korea, Republic of)

Purpose: To evaluate the suitability of the GD-301 glass dosimeter for in vivo dose verification in proton therapy. Methods and Materials: The glass dosimeter was analyzed for its dosimetrics characteristic in proton beam. Dosimeters were calibrated in a water phantom using a stairlike holder specially designed for this study. To determine the accuracy of the glass dosimeter in proton dose measurements, we compared the glass dosimeter and thermoluminescent dosimeter (TLD) dose measurements using a cylindrical phantom. We investigated the feasibility of the glass dosimeter for the measurement of dose distributions near the superficial region for proton therapy plans with a varying separation between the target volume and the surface of 6 patients. Results and Discussion: Uniformity was within 1.5%. The dose-response has good linearity. Dose-rate, fading, and energy dependence were found to be within 3%. The beam profile measured using the glass dosimeter was in good agreement with the profile obtained from the ionization chamber. Depth-dose distributions in nonmodulated and modulated proton beams obtained with the glass dosimeter were estimated to be within 3%, which was lower than those with the ionization chamber. In the phantom study, the difference of isocenter dose between the delivery dose calculated by the treatment planning system and that measured by the glass dosimeter was within 5%. With in vivo dosimetry, the calculated surface doses overestimated measurements by 4%-16% using glass dosimeter and TLD. Conclusion: It is recommended that bolus be added for these clinical cases. We also believe that the glass dosimeter has considerable potential for use with in vivo patient proton dosimetry.

• OSTI ID: 22149547
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 2 Vol. 84; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BEAM PROFILES
DEPTH DOSE DISTRIBUTIONS
DOSE RATES
FEASIBILITY STUDIES
GLASS
IN VIVO
IONIZATION CHAMBERS
PATIENTS
PHANTOMS
PLANNING
PROTON BEAMS
PROTON DOSIMETRY
RADIATION DOSES
RADIOTHERAPY
THERMOLUMINESCENT DOSEMETERS
VERIFICATION
WATER