HSPB1 Gene Polymorphisms Predict Risk of Mortality for US Patients After Radio(chemo)therapy for Non-Small Cell Lung Cancer

Journal Article · Mon Oct 01 04:00:00 EDT 2012 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2012.03.032· OSTI ID:22149532

Ting, Xu ^[1]; Qingyi, Wei ^[2]; Lopez Guerra, Jose Luis ^[3]; Lie, Wang; Zhensheng, Liu ^[2]; Gomez, Daniel; O'Reilly, Michael; Lin, Steven Hsesheng ^[3]; Yan, Zhuang ^[4]; Levy, Lawrence B. ^[3]; Mohan, Radhe ^[4]; Honghao, Zhou ^[1]

---

1. Institute of Clinical Pharmacology, Central South University, Changsha, Hunan (China)
2. Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)
3. Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)
4. Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

Purpose: We investigated potential associations between single-nucleotide polymorphisms (SNPs) in the heat shock protein beta-1 (HSPB1) gene and overall survival in US patients with non-small cell lung cancer (NSCLC). Methods and Materials: Using available genomic DNA samples from 224 patients with NSCLC treated with definitive radio(chemo)therapy, we genotyped 2 SNPs of HSPB1 (NCBI SNP nos. rs2868370 and rs2868371). We used both Kaplan-Meier cumulative probability and Cox proportional hazards analyses to evaluate the effect of HSPB1 genotypes on survival. Results: Our cohort consisted of 117 men and 107 women, mostly white (79.5%), with a median age of 70 years. The median radiation dose was 66 Gy (range, 63-87.5 Gy), and 183 patients (82%) received concurrent platinum-based chemotherapy. The most common genotype of the rs2868371 SNP was CC (61%). Univariate and multivariate analyses showed that this genotype was associated with poorer survival than CG and GG genotypes (univariate hazard ratio [HR] = 1.39, 95% confidence interval [CI], 1.02-1.90; P=.037; multivariate HR = 1.39; 95% CI, 1.01-1.92; P=.045). Conclusions: Our results showed that the CC genotype of HSPB1 rs2868371 was associated with poorer overall survival in patients with NSCLC after radio(chemo)therapy, findings that contradict those of a previous study of Chinese patients. Validation of our findings with larger numbers of similar patients is needed, as are mechanical and clinical studies to determine the mechanism underlying these associations.

• OSTI ID: 22149532
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 2 Vol. 84; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CHEMOTHERAPY
DNA
GENES
GENOTYPE
GY RANGE 10-100
HEALTH HAZARDS
HEAT-SHOCK PROTEINS
LUNGS
MEN
MORTALITY
MULTIVARIATE ANALYSIS
NEOPLASMS
NUCLEOTIDES
PATIENTS
PLATINUM COMPLEXES
RADIATION DOSES
VALIDATION
WOMEN