The role of MAPK in CD4{sup +} T cells toll-like receptor 9-mediated signaling following HHV-6 infection

Journal Article · Thu Jan 05 04:00:00 EST 2012 · Virology

DOI:https://doi.org/10.1016/J.VIROL.2011.09.026· OSTI ID:22149251

Chi, Jing ^[1]; Wang, Fang ^[2]; Li, Lingyun ^[3]; Feng, Dongju ^[1]; Qin, Jian ^[4]; Xie, Fangyi; Zhou, Feng; Chen, Yun; Wang, Jinfeng ^[1]; Yao, Kun ^[1]

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1. Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, Jiangsu Province (China)
2. Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province (China)
3. Department of Developmental Genetics, Nanjing Medical University, Nanjing 210029, Jiangsu Province (China)
4. College of Foreign Languages, Hehai University, Nanjing 210029, Jiangsu Province (China)

Human herpesvirus-6 (HHV-6) is an important immunosuppressive and immunomodulatory virus that primarily infects immune cells (mainly CD4{sup +} T cells) and strongly suppresses the proliferation of infected cells. Toll-like receptors are pattern-recognition receptors essential for the development of an appropriate innate immune defense against infection. To understand the role of CD4{sup +} T cells in the innate response to HHV-6 infection and the involvement of TLRs, we used an in vitro infection model and observed that the infection of CD4{sup +} T cells resulted in the activation of JNK/SAPK via up-regulation of toll-like receptor 9 (TLR9). Associated with JNK activation, annexin V-PI staining indicated that HHV-6A was a strong inducer of apoptosis. Apoptotic response associated cytokines, IL-6 and TNF-{alpha} also induced by HHV-6A infection.

• OSTI ID: 22149251
• Journal Information: Virology, Journal Name: Virology Journal Issue: 1 Vol. 422; ISSN VIRLAX; ISSN 0042-6822
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
APOPTOSIS
CELL PROLIFERATION
IN VITRO
LYMPHOKINES
RECEPTORS
VIRUSES