Correlations of urinary cadmium with hypertension and diabetes in persons living in cadmium-contaminated villages in northwestern Thailand: A population study

Journal Article · Sun Aug 15 04:00:00 EDT 2010 · Environmental Research

DOI:https://doi.org/10.1016/J.ENVRES.2010.06.002· OSTI ID:22149226

Swaddiwudhipong, Witaya ^[1]; Mahasakpan, Pranee ^[1]; Limpatanachote, Pisit; Krintratun, Somyot ^[2]

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1. Department of Community and Social Medicine, Mae Sot General Hospital, Tak 63110 (Thailand)
2. Department of Internal Medicine, Mae Sot General Hospital, Tak (Thailand)

Risk for hypertension and diabetes has not been conclusively found to be a result of cadmium exposure. A population-based study was conducted in 2009 to examine the correlations of urinary cadmium, a good biomarker of long-term cadmium exposure, with hypertension and diabetes in persons aged 35 years and older who lived in the 12 cadmium-contaminated rural villages in northwestern Thailand. A total of 5273 persons were interviewed and screened for urinary cadmium, hypertension, and diabetes. The geometric mean level of urinary cadmium for women (2.4{+-}2.3 {mu}g/g creatinine) was significantly greater than that for men (2.0{+-}2.2 {mu}g/g creatinine). Hypertension was presented in 29.8% of the study population and diabetes was detected in 6.6%. The prevalence of hypertension significantly increased from 25.0% among persons in the lowest tertile of urinary cadmium to 35.0% in the highest tertile. In women, the rate of hypertension significantly increased with increasing urinary cadmium levels in both ever and never smokers, after adjusting for age, alcohol consumption, body mass index, and diabetes. In men, such association was less significantly found in never smokers. The study revealed no significant association between urinary cadmium and diabetes in either gender. Our study supports the hypothesis that environmental exposure to cadmium may increase the risk of hypertension. Risk for diabetes in relation to cadmium exposure remains uncertain in this exposed population.

• OSTI ID: 22149226
• Journal Information: Environmental Research, Journal Name: Environmental Research Journal Issue: 6 Vol. 110; ISSN ENVRAL; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ALCOHOLS
BIOLOGICAL MARKERS
CADMIUM
CREATININE
ENVIRONMENTAL EXPOSURE
HEALTH HAZARDS
HYPERTENSION
TOBACCO SMOKES