Chemically reactive species in liquids generated by atmospheric-pressure plasmas and their roles in plasma medicine

Journal Article · Thu Jul 11 00:00:00 EDT 2013 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.4815857· OSTI ID:22121641

Hamaguchi, Satoshi ^[1]

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1. Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871 (Japan)

Plasmas whose gas temperatures are close to room temperature may be generated in ambient air or a gas at atmospheric pressure with the use of low-frequency high voltage or low-power radio-frequency (RF) or microwave power applied to electrodes. Such plasmas can serve as a powerful source of free radicals and/or chemically reactive species that arise from atoms and molecules of the ambient gas. Recently use of such plasmas for medical purposes has attracted much attention as they can be implemented in possible medical devices that can cause blood coagulation, heal wounds, facilitate angiogenesis, sterilize surgical devices as well as living tissues without harming healthy cells, and selectively inactivate cancer cells. Especially of interest among reactive species generated by atmospheric-pressure plasmas (APP) are reactive oxygen species (ROS) and reactive nitrogen species (RNS) that are generated in liquid phase. Since most living tissues and cells are immersed in liquids (such as blood or culture media), reactive species generated by APPs in the gas phase are transported to the liquid phase and possibly converted to different types of reactive species therein before causing some influence on the tissues or cells. In this study, the rate equations are solved to evaluate concentrations of various reactive species in pure water that are originated by plasma reactions in atmosphere and possible effects of such species (including ROS/RNS) on living tissues and cells are discussed.

• OSTI ID: 22121641
• Journal Information: AIP Conference Proceedings, Vol. 1545, Issue 1; Conference: ICAMDATA-2012: 8. international conference on atomic and molecular data and their applications, Gaithersburg, MD (United States), 30 Sep - 4 Oct 2012; Other Information: (c) 2013 AIP Publishing LLC; Country of input: International Atomic Energy Agency (IAEA); ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
60 APPLIED LIFE SCIENCES
70 PLASMA PHYSICS AND FUSION TECHNOLOGY
AIR
ANGIOGENESIS
ANIMAL TISSUES
ATMOSPHERIC PRESSURE
BLOOD
BLOOD COAGULATION
CHEMICAL REACTION KINETICS
CONCENTRATION RATIO
ELECTRIC POTENTIAL
MICROWAVE RADIATION
NITROGEN
OXYGEN
PLASMA
RADICALS
RADIOWAVE RADIATION
TEMPERATURE RANGE 0273-0400 K
THERMODYNAMIC ACTIVITY
WATER