Computer-aided detection of breast masses: Four-view strategy for screening mammography

Journal Article · Fri Apr 15 04:00:00 EDT 2011 · Medical Physics

DOI:https://doi.org/10.1118/1.3560462· OSTI ID:22096963

Jun, Wei; Heangping, Chan; Chuan, Zhou; Yita, Wu; Sahiner, Berkman; Hadjiiski, Lubomir M.; Roubidoux, Marilyn A.; Helvie, Mark A. ^[1]

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1. Department of Radiology, University of Michigan, 1500 East Medical Center Drive, C478 Med-Inn Building, Ann Arbor, Michigan 48109-5842 (United States)

Purpose: To improve the performance of a computer-aided detection (CAD) system for mass detection by using four-view information in screening mammography. Methods: The authors developed a four-view CAD system that emulates radiologists' reading by using the craniocaudal and mediolateral oblique views of the ipsilateral breast to reduce false positives (FPs) and the corresponding views of the contralateral breast to detect asymmetry. The CAD system consists of four major components: (1) Initial detection of breast masses on individual views, (2) information fusion of the ipsilateral views of the breast (referred to as two-view analysis), (3) information fusion of the corresponding views of the contralateral breast (referred to as bilateral analysis), and (4) fusion of the four-view information with a decision tree. The authors collected two data sets for training and testing of the CAD system: A mass set containing 389 patients with 389 biopsy-proven masses and a normal set containing 200 normal subjects. All cases had four-view mammograms. The true locations of the masses on the mammograms were identified by an experienced MQSA radiologist. The authors randomly divided the mass set into two independent sets for cross validation training and testing. The overall test performance was assessed by averaging the free response receiver operating characteristic (FROC) curves of the two test subsets. The FP rates during the FROC analysis were estimated by using the normal set only. The jackknife free-response ROC (JAFROC) method was used to estimate the statistical significance of the difference between the test FROC curves obtained with the single-view and the four-view CAD systems. Results: Using the single-view CAD system, the breast-based test sensitivities were 58% and 77% at the FP rates of 0.5 and 1.0 per image, respectively. With the four-view CAD system, the breast-based test sensitivities were improved to 76% and 87% at the corresponding FP rates, respectively. The improvement was found to be statistically significant (p<0.0001) by JAFROC analysis. Conclusions: The four-view information fusion approach that emulates radiologists' reading strategy significantly improves the performance of breast mass detection of the CAD system in comparison with the single-view approach.

• OSTI ID: 22096963
• Journal Information: Medical Physics, Journal Name: Medical Physics Journal Issue: 4 Vol. 38; ISSN 0094-2405; ISSN MPHYA6
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
71 CLASSICAL AND QUANTUM MECHANICS
GENERAL PHYSICS
BIOMEDICAL RADIOGRAPHY
BIOPSY
DECISION TREE ANALYSIS
IMAGE PROCESSING
IMAGES
MAMMARY GLANDS
PATIENTS
PERFORMANCE
SCREENING
SENSITIVITY
SENSITIVITY ANALYSIS
TRAINING
VALIDATION