Comparison of radiograph-based texture analysis and bone mineral density with three-dimensional microarchitecture of trabecular bone

Journal Article · Sat Jan 15 04:00:00 EST 2011 · Medical Physics

DOI:https://doi.org/10.1118/1.3528125· OSTI ID:22096878

Ranjanomennahary, P.; Ghalila, S. Sevestre; Malouche, D; Marchadier, A.; Rachidi, M.; Benhamou, Cl.; Chappard, C. ^[1]; U2S ENIT, 1002 Tunis ^[2]

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1. Caracteristation du Tissu Osseux par Imagerie, U658 Inserm, Orleans (France)
2. Tunisia

Purpose: Hip fracture is a serious health problem and textural methods are being developed to assess bone quality. The authors aimed to perform textural analysis at femur on high-resolution digital radiographs compared to three-dimensional (3D) microarchitecture comparatively to bone mineral density. Methods: Sixteen cadaveric femurs were imaged with an x-ray device using a C-MOS sensor. One 17 mm square region of interest (ROI) was selected in the femoral head (FH) and one in the great trochanter (GT). Two-dimensional (2D) textural features from the co-occurrence matrices were extracted. Site-matched measurements of bone mineral density were performed. Inside each ROI, a 16 mm diameter core was extracted. Apparent density (D{sub app}) and bone volume proportion (BV/TV{sub Arch}) were measured from a defatted bone core using Archimedes' principle. Microcomputed tomography images of the entire length of the core were obtained (Skyscan 1072) at 19.8 {mu}m of resolution and usual 3D morphometric parameters were computed on the binary volume after calibration from BV/TV{sub Arch}. Then, bone surface/bone volume, trabecular thickness, trabecular separation, and trabecular number were obtained by direct methods without model assumption and the structure model index was calculated. Results: In univariate analysis, the correlation coefficients between 2D textural features and 3D morphological parameters reached 0.83 at the FH and 0.79 at the GT. In multivariate canonical correlation analysis, coefficients of the first component reached 0.95 at the FH and 0.88 at the GT. Conclusions: Digital radiographs, widely available and economically viable, are an alternative method for evaluating bone microarchitectural structure.

• OSTI ID: 22096878
• Journal Information: Medical Physics, Journal Name: Medical Physics Journal Issue: 1 Vol. 38; ISSN 0094-2405; ISSN MPHYA6
• Country of Publication: United States
• Language: English

Related Subjects

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
CALIBRATION
COMPUTERIZED TOMOGRAPHY
DENSITY
ECONOMICS
FEMUR
FRACTURES
IMAGE PROCESSING
IMAGES
MULTIVARIATE ANALYSIS
OSTEOPOROSIS
SENSORS
SURFACES
TRABECULAR BONE
X RADIATION