Cyclotron production of {sup 61}Cu using natural Zn and enriched {sup 64}Zn targets

Journal Article · Wed Dec 19 04:00:00 EST 2012 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.4773947· OSTI ID:22075959

Asad, A H; Smith, S V; Chan, S; Jeffery, C M; Morandeau, L; Price, R I ^[1]

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1. RAPID PET Labs, Medical Technology and Physics, Sir Charles Gairdner Hospital, Perth, Australia, Imaging and Applied Physics, Curtin University, Perth, Australia, and Center of Excellence in Anti-matter Matter Studies, Australian National University, Can (Australia)

Copper-61 ({sup 61}Cu) shares with {sup 64}Cu certain advantages for PET diagnostic imaging, but has a shorter half-life (3.4hr vs. 12.7hr) and a greater probability of positron production per disintegration (61% vs. 17.9%). One important application is for in vivo imaging of hypoxic tissue. In this study {sup 61}Cu was produced using the {sup 64}Zn(p,{alpha}){sup 61}Cu reaction on natural Zn or enriched {sup 64}Zn targets. The enriched {sup 64}Zn (99.82%) was electroplated onto high purity gold or silver foils or onto thin Al discs. A typical target bombardment used 30{mu}A; at 11.7, 14.5 or 17.6MeV over 30-60min. The {sup 61}Cu (radiochemical purity of >95%) was separated using a combination of cation and anion exchange columns. The {sup 64}Zn target material was recovered after each run, for re-use. In a direct comparison with enriched {sup 64}Zn-target results, {sup 61}Cu production using the cheaper {sup nat}Zn target proved to be an effective alternative.

• OSTI ID: 22075959
• Journal Information: AIP Conference Proceedings, Journal Name: AIP Conference Proceedings Journal Issue: 1 Vol. 1509; ISSN APCPCS; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

07 ISOTOPE AND RADIATION SOURCES
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
ALPHA PARTICLES
COMPARATIVE EVALUATIONS
COPPER 61
COPPER 64
CYCLOTRONS
ELECTROPLATING
FOILS
GOLD
HALF-LIFE
ION EXCHANGE
ISOTOPE PRODUCTION
ISOTOPE SEPARATION
PROTON REACTIONS
RADIOCHEMISTRY
SILVER
ZINC 64 TARGET