Ghrelin Suppression and Fat Loss after Left Gastric Artery Embolization in Canine Model

Journal Article · Sat Dec 15 04:00:00 EST 2012 · Cardiovascular and Interventional Radiology

DOI:https://doi.org/10.1007/S00270-012-0362-8· OSTI ID:22066496

Bawudun, Dilmurat ^[1]; Yan, Xing; Yujie, Huang ^[2]; Weixin, Ren ^[1]; Mei, Ma ^[3]; Xiaodong, Xu ^[1]; Gaojun, Teng ^[4]

---

1. Xinjiang Medical University, Department of Interventional Radiology, First Affiliated Hospital (China)
2. Xinjiang Medical University, Imaging Center, First Affiliated Hospital (China)
3. Xinjiang Medical University, Animal Research Center, First Affiliated Hospital (China)
4. Southeast University, Department of Radiology, Zhong-da Hospital (China)

Purpose: To evaluate the effects of left gastric artery embolization (LGAE) on plasma ghrelin levels, abdominal fat, and body weight in beagles. Methods: The institutional animal care and use committee approved this study. Fifteen healthy adult beagles (12 male and three female animals) were randomly divided into three experimental groups: LGAE was proceeded with mixed emulsion of bleomycin A{sub 5} hydrochloride and lipiodol (group A), and polyvinyl alcohol particles (group B). Transcatheter saline injections in the left gastric artery were performed as a control. Weight and fasting plasma ghrelin levels were obtained at baseline and at weekly intervals for 8 weeks after the procedure in all animals. All animals were scanned and measured by multidetector computed tomography at baseline and at week 8 for evaluation of abdominal fat. Results: In LGAE-treated animals, plasma ghrelin and body weight significantly decreased compared to control animals (group A: P = 0.007 and P = 0.000; group B: P = 0.004 and P = 0.000, respectively). Subcutaneous fat size was also significantly reduced (P = 0.011 and P = 0.027 for groups A and B, respectively). The decreasing percentage in ghrelin levels at week 6 (peak of recovery) of LGAE-treated animals were negatively correlated with the size of area supplied by left gastric artery (r = -0.693, P = 0.026). Conclusion: LGAE could suppress the plasma concentration of ghrelin, which results in subcutaneous fat size reduction and weight loss. Compensatory ghrelin production might occur in the remnant gastric fundus after LGAE.

• OSTI ID: 22066496
• Journal Information: Cardiovascular and Interventional Radiology, Journal Name: Cardiovascular and Interventional Radiology Journal Issue: 6 Vol. 35; ISSN 0174-1551; ISSN CAIRDG
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
BEAGLES
BLEOMYCIN
BLOOD PLASMA
COMPUTERIZED TOMOGRAPHY
EMBOLI
EVALUATION
FATS
INJECTION
LIPIODOL
PVA