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Title: Dynamic Contrast-Enhanced MRI of Cervical Cancers: Temporal Percentile Screening of Contrast Enhancement Identifies Parameters for Prediction of Chemoradioresistance

Abstract

Purpose: To systematically screen the tumor contrast enhancement of locally advanced cervical cancers to assess the prognostic value of two descriptive parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Methods and Materials: This study included a prospectively collected cohort of 81 patients who underwent DCE-MRI with gadopentetate dimeglumine before chemoradiotherapy. The following descriptive DCE-MRI parameters were extracted voxel by voxel and presented as histograms for each time point in the dynamic series: normalized relative signal increase (nRSI) and normalized area under the curve (nAUC). The first to 100th percentiles of the histograms were included in a log-rank survival test, resulting in p value and relative risk maps of all percentile-time intervals for each DCE-MRI parameter. The maps were used to evaluate the robustness of the individual percentile-time pairs and to construct prognostic parameters. Clinical endpoints were locoregional control and progression-free survival. The study was approved by the institutional ethics committee. Results: The p value maps of nRSI and nAUC showed a large continuous region of percentile-time pairs that were significantly associated with locoregional control (p < 0.05). These parameters had prognostic impact independent of tumor stage, volume, and lymph node status on multivariate analysis. Only a small percentile-time intervalmore » of nRSI was associated with progression-free survival. Conclusions: The percentile-time screening identified DCE-MRI parameters that predict long-term locoregional control after chemoradiotherapy of cervical cancer.« less

Authors:
 [1]; ;  [2];  [3];  [3];  [4];  [5];  [1];  [4]
  1. Department of Medical Physics, Oslo University Hospital, Oslo (Norway)
  2. Department of Radiology, Oslo University Hospital, Oslo (Norway)
  3. Department of Gynaecological Oncology, Oslo University Hospital, Oslo (Norway)
  4. (Norway)
  5. Department of Radiation Biology, Oslo University Hospital, Oslo (Norway)
Publication Date:
OSTI Identifier:
22056134
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 82; Journal Issue: 3; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; COMBINED THERAPY; ETHICAL ASPECTS; FEMALE GENITALS; FORECASTING; GADOLINIUM COMPOUNDS; HAZARDS; LYMPH NODES; MULTIVARIATE ANALYSIS; NEOPLASMS; NMR IMAGING; PATIENTS; RADIOTHERAPY

Citation Formats

Andersen, Erlend K.F., Hole, Knut Hakon, Lund, Kjersti V., Sundfor, Kolbein, Kristensen, Gunnar B., Institute for Medical Informatics, Oslo University Hospital, Oslo, Lyng, Heidi, Malinen, Eirik, E-mail: eirik.malinen@fys.uio.no, and Department of Physics, University of Oslo, Oslo. Dynamic Contrast-Enhanced MRI of Cervical Cancers: Temporal Percentile Screening of Contrast Enhancement Identifies Parameters for Prediction of Chemoradioresistance. United States: N. p., 2012. Web. doi:10.1016/J.IJROBP.2011.05.050.
Andersen, Erlend K.F., Hole, Knut Hakon, Lund, Kjersti V., Sundfor, Kolbein, Kristensen, Gunnar B., Institute for Medical Informatics, Oslo University Hospital, Oslo, Lyng, Heidi, Malinen, Eirik, E-mail: eirik.malinen@fys.uio.no, & Department of Physics, University of Oslo, Oslo. Dynamic Contrast-Enhanced MRI of Cervical Cancers: Temporal Percentile Screening of Contrast Enhancement Identifies Parameters for Prediction of Chemoradioresistance. United States. doi:10.1016/J.IJROBP.2011.05.050.
Andersen, Erlend K.F., Hole, Knut Hakon, Lund, Kjersti V., Sundfor, Kolbein, Kristensen, Gunnar B., Institute for Medical Informatics, Oslo University Hospital, Oslo, Lyng, Heidi, Malinen, Eirik, E-mail: eirik.malinen@fys.uio.no, and Department of Physics, University of Oslo, Oslo. Thu . "Dynamic Contrast-Enhanced MRI of Cervical Cancers: Temporal Percentile Screening of Contrast Enhancement Identifies Parameters for Prediction of Chemoradioresistance". United States. doi:10.1016/J.IJROBP.2011.05.050.
@article{osti_22056134,
title = {Dynamic Contrast-Enhanced MRI of Cervical Cancers: Temporal Percentile Screening of Contrast Enhancement Identifies Parameters for Prediction of Chemoradioresistance},
author = {Andersen, Erlend K.F. and Hole, Knut Hakon and Lund, Kjersti V. and Sundfor, Kolbein and Kristensen, Gunnar B. and Institute for Medical Informatics, Oslo University Hospital, Oslo and Lyng, Heidi and Malinen, Eirik, E-mail: eirik.malinen@fys.uio.no and Department of Physics, University of Oslo, Oslo},
abstractNote = {Purpose: To systematically screen the tumor contrast enhancement of locally advanced cervical cancers to assess the prognostic value of two descriptive parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Methods and Materials: This study included a prospectively collected cohort of 81 patients who underwent DCE-MRI with gadopentetate dimeglumine before chemoradiotherapy. The following descriptive DCE-MRI parameters were extracted voxel by voxel and presented as histograms for each time point in the dynamic series: normalized relative signal increase (nRSI) and normalized area under the curve (nAUC). The first to 100th percentiles of the histograms were included in a log-rank survival test, resulting in p value and relative risk maps of all percentile-time intervals for each DCE-MRI parameter. The maps were used to evaluate the robustness of the individual percentile-time pairs and to construct prognostic parameters. Clinical endpoints were locoregional control and progression-free survival. The study was approved by the institutional ethics committee. Results: The p value maps of nRSI and nAUC showed a large continuous region of percentile-time pairs that were significantly associated with locoregional control (p < 0.05). These parameters had prognostic impact independent of tumor stage, volume, and lymph node status on multivariate analysis. Only a small percentile-time interval of nRSI was associated with progression-free survival. Conclusions: The percentile-time screening identified DCE-MRI parameters that predict long-term locoregional control after chemoradiotherapy of cervical cancer.},
doi = {10.1016/J.IJROBP.2011.05.050},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 3,
volume = 82,
place = {United States},
year = {2012},
month = {3}
}