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Title: Second Malignant Neoplasms in Digestive Organs After Childhood Cancer: A Cohort-Nested Case-Control Study

Abstract

Purpose: Cancers of the digestive system constitute a major risk for childhood cancer survivors treated with radiotherapy once they reach adulthood. The aim of this study was to determine therapy-related risk factors for the development of a second malignancy in the digestive organs (SMDO) after a childhood cancer. Methods and Materials: Among 4,568 2-year survivors of a childhood solid cancer diagnosed before 17 years of age at eight French and British centers, and among 25,120 patients diagnosed as having a malignant neoplasm before the age of 20 years, whose data were extracted from the Nordic Cancer Registries, we matched 58 case patients (41 men and 17 women) of SMDO and 167 controls, in their respective cohort, for sex, age at first cancer, calendar year of occurrence of the first cancer, and duration of follow-up. The radiation dose received at the site of each second malignancy and at the corresponding site of its matched control was estimated. Results: The risk of developing a SMDO was 9.7-fold higher in relation to the general populations in France and the United Kingdom. In the case-control study, a strong dose-response relationship was estimated, compared with that in survivors who had not received radiotherapy; the oddsmore » ratio was 5.2 (95% CI, 1.7-16.0) for local radiation doses between 10 and 29 Gy and 9.6 (95% CI, 2.6-35.2) for doses equal to or greater than 30 Gy. Chemotherapy was also found to increase the risk of developing SMDO. Conclusions: This study confirms that childhood cancer treatments strongly increase the risk of SMDO, which occur only after a very long latency period.« less

Authors:
;  [1];  [2];  [3];  [4];  [5];  [1];  [3];  [1];  [1]; ;  [1];  [2];  [5];
  1. Radiation Epidemiology Group, CESP Center for Research in Epidemiology and Population Health, INSERM, Villejuif (France)
  2. Department of Cancer Epidemiology, Lund University, Lund (Sweden)
  3. Center for Childhood Cancer Survivor Studies, Department of Public Health and Epidemiology, University of Birmingham, Birmingham (United Kingdom)
  4. Childhood Cancer Research Center, University Children's Hospital, Lund (Sweden)
  5. Finnish Cancer Registry, Helsinki (Finland)
Publication Date:
OSTI Identifier:
22056105
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 82; Journal Issue: 3; Other Information: Copyright (c) 2012 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CHEMOTHERAPY; CONTROL; DIGESTIVE SYSTEM; DOSE-RESPONSE RELATIONSHIPS; HAZARDS; LATENCY PERIOD; MEN; NEOPLASMS; PATIENTS; RADIATION DOSES; RADIOTHERAPY; SEX; WOMEN

Citation Formats

Tukenova, Markhaba, Diallo, Ibrahima, University Paris Sud 11, UMRS, Villejuif, Gustave Roussy Institute, Villejuif, Anderson, Harald, Hawkins, Mike, Garwicz, Stanislaw, Sankila, Risto, El Fayech, Chiraz, University Paris Sud 11, UMRS, Villejuif, Gustave Roussy Institute, Villejuif, Winter, Dave, Rubino, Carole, University Paris Sud 11, UMRS, Villejuif, Gustave Roussy Institute, Villejuif, Adjadj, Elisabeth, University Paris Sud 11, UMRS, Villejuif, Gustave Roussy Institute, Villejuif, Curie Institute, Paris, Haddy, Nadia, Oberlin, Odile, University Paris Sud 11, UMRS, Villejuif, Gustave Roussy Institute, Villejuif, Moller, Torgil, Langmark, Froydis, and others, and. Second Malignant Neoplasms in Digestive Organs After Childhood Cancer: A Cohort-Nested Case-Control Study. United States: N. p., 2012. Web. doi:10.1016/J.IJROBP.2011.05.069.
Tukenova, Markhaba, Diallo, Ibrahima, University Paris Sud 11, UMRS, Villejuif, Gustave Roussy Institute, Villejuif, Anderson, Harald, Hawkins, Mike, Garwicz, Stanislaw, Sankila, Risto, El Fayech, Chiraz, University Paris Sud 11, UMRS, Villejuif, Gustave Roussy Institute, Villejuif, Winter, Dave, Rubino, Carole, University Paris Sud 11, UMRS, Villejuif, Gustave Roussy Institute, Villejuif, Adjadj, Elisabeth, University Paris Sud 11, UMRS, Villejuif, Gustave Roussy Institute, Villejuif, Curie Institute, Paris, Haddy, Nadia, Oberlin, Odile, University Paris Sud 11, UMRS, Villejuif, Gustave Roussy Institute, Villejuif, Moller, Torgil, Langmark, Froydis, & others, and. Second Malignant Neoplasms in Digestive Organs After Childhood Cancer: A Cohort-Nested Case-Control Study. United States. https://doi.org/10.1016/J.IJROBP.2011.05.069
Tukenova, Markhaba, Diallo, Ibrahima, University Paris Sud 11, UMRS, Villejuif, Gustave Roussy Institute, Villejuif, Anderson, Harald, Hawkins, Mike, Garwicz, Stanislaw, Sankila, Risto, El Fayech, Chiraz, University Paris Sud 11, UMRS, Villejuif, Gustave Roussy Institute, Villejuif, Winter, Dave, Rubino, Carole, University Paris Sud 11, UMRS, Villejuif, Gustave Roussy Institute, Villejuif, Adjadj, Elisabeth, University Paris Sud 11, UMRS, Villejuif, Gustave Roussy Institute, Villejuif, Curie Institute, Paris, Haddy, Nadia, Oberlin, Odile, University Paris Sud 11, UMRS, Villejuif, Gustave Roussy Institute, Villejuif, Moller, Torgil, Langmark, Froydis, and others, and. 2012. "Second Malignant Neoplasms in Digestive Organs After Childhood Cancer: A Cohort-Nested Case-Control Study". United States. https://doi.org/10.1016/J.IJROBP.2011.05.069.
@article{osti_22056105,
title = {Second Malignant Neoplasms in Digestive Organs After Childhood Cancer: A Cohort-Nested Case-Control Study},
author = {Tukenova, Markhaba and Diallo, Ibrahima and University Paris Sud 11, UMRS, Villejuif and Gustave Roussy Institute, Villejuif and Anderson, Harald and Hawkins, Mike and Garwicz, Stanislaw and Sankila, Risto and El Fayech, Chiraz and University Paris Sud 11, UMRS, Villejuif and Gustave Roussy Institute, Villejuif and Winter, Dave and Rubino, Carole and University Paris Sud 11, UMRS, Villejuif and Gustave Roussy Institute, Villejuif and Adjadj, Elisabeth and University Paris Sud 11, UMRS, Villejuif and Gustave Roussy Institute, Villejuif and Curie Institute, Paris and Haddy, Nadia and Oberlin, Odile and University Paris Sud 11, UMRS, Villejuif and Gustave Roussy Institute, Villejuif and Moller, Torgil and Langmark, Froydis and others, and},
abstractNote = {Purpose: Cancers of the digestive system constitute a major risk for childhood cancer survivors treated with radiotherapy once they reach adulthood. The aim of this study was to determine therapy-related risk factors for the development of a second malignancy in the digestive organs (SMDO) after a childhood cancer. Methods and Materials: Among 4,568 2-year survivors of a childhood solid cancer diagnosed before 17 years of age at eight French and British centers, and among 25,120 patients diagnosed as having a malignant neoplasm before the age of 20 years, whose data were extracted from the Nordic Cancer Registries, we matched 58 case patients (41 men and 17 women) of SMDO and 167 controls, in their respective cohort, for sex, age at first cancer, calendar year of occurrence of the first cancer, and duration of follow-up. The radiation dose received at the site of each second malignancy and at the corresponding site of its matched control was estimated. Results: The risk of developing a SMDO was 9.7-fold higher in relation to the general populations in France and the United Kingdom. In the case-control study, a strong dose-response relationship was estimated, compared with that in survivors who had not received radiotherapy; the odds ratio was 5.2 (95% CI, 1.7-16.0) for local radiation doses between 10 and 29 Gy and 9.6 (95% CI, 2.6-35.2) for doses equal to or greater than 30 Gy. Chemotherapy was also found to increase the risk of developing SMDO. Conclusions: This study confirms that childhood cancer treatments strongly increase the risk of SMDO, which occur only after a very long latency period.},
doi = {10.1016/J.IJROBP.2011.05.069},
url = {https://www.osti.gov/biblio/22056105}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 3,
volume = 82,
place = {United States},
year = {2012},
month = {3}
}