The Role of Pretreatment FDG-PET in Nasopharyngeal Carcinoma Treated With Intensity-Modulated Radiotherapy

Journal Article · Wed Feb 01 04:00:00 EST 2012 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2010.11.055· OSTI ID:22055995

Liu, Wen-Shan ^[1]; Wu, Ming-Fang ^[2]; Tseng, Hsien-Chun ^[1]; Liu, Jung-Tung ^[3]; Weng, Jui-Hung ^[4]; Li, Yueh-Chun ^[1]; Lee, Jong-Kang ^[5]

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1. School of Medicine, Chung Shan Medical University and Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung, Taiwan (China)
2. School of Medicine, Chung Shan Medical University and Division of Medical Oncology, Chung Shan Medical University Hospital, Taichung, Taiwan (China)
3. School of Medicine, Chung Shan Medical University and Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan (China)
4. Department of Nuclear Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan (China)
5. School of Medicine, Chung Shan Medical University and Department of Nuclear Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan (China)

Purpose: Pretreatment with 2- [{sup 18}F] fluorodeoxyglucose positron emission tomography ({sup 18}F-FDG-PET) was evaluated as a predictor of local failure-free survival (LFFS), disease-free survival (DFS), and overall survival (OS) in patients with nonkeratinizing nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiation therapy (IMRT) alone or concurrently with chemotherapy (CCRT). Patients and Methods: Seventy-five M0 NPC patients who received FDG-PET before treatment were analyzed. The primary tumor FDG uptake was measured as the maximum standardized uptake value (SUVmax). The LFFS, DFS, and OS were calculated by the Kaplan-Meier method, and the differences were evaluated on log-rank test. The prognostic significance was assessed by univariate and multivariate analyses. Results: Eighteen patients received IMRT alone and 57 received CCRT. The mean SUVmax was significantly higher in 12 patients with locoregional or distant failure than in those without failure (p <0.001). On multivariate analysis, the SUVmax was the only significant variable for 5-year LFFS (p = 0.017) and DFS (p = 0.000) but not for OS (p = 0.065). Conclusion: SUVmax is a potential independent prognostic predictor of clinical outcomes in patients with nasopharyngeal carcinoma treated with IMRT alone or with CCRT. A high {sup 18}F-FDG uptake (SUVmax >5) indicates poor outcome in patients with NPC.

• OSTI ID: 22055995
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 2 Vol. 82; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
CHEMOTHERAPY
FAILURES
FLUORINE 18
FLUORODEOXYGLUCOSE
MULTIVARIATE ANALYSIS
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
RADIOTHERAPY