Small-angle neutron scattering from polymer hydrogels with memory effect for medicine immobilization

Journal Article · Thu Dec 15 00:00:00 EST 2011 · Crystallography Reports

DOI:https://doi.org/10.1134/S1063774511070170· OSTI ID:22054233

Lebedev, V T; Trunov, V A ^[1]; Pavlyuchenko, V N ^[2]; Ivanchev, S S; Primachenko, O N; Khaikin, S Ya ^[3]

---

1. Russian Academy of Sciences, Orlova roshcha, Konstantinov Nuclear Physics Institute (Russian Federation)
2. Kirov Military Medical Academy (Russian Federation)
3. Boreskov Institute of Catalysis, St. Petersburg Branch (Russian Federation)

Hydrogels synthesized based on cross-linked copolymers of 2-hydroxyethyl methacrylate and functional monomers (acrylic acid or dimethylaminoethyl methacrylate), having a memory effect with respect to target medicine (cefazolin), have been investigated by small-angle neutron scattering. The hydrogels are found to have a two-level structural organization: large (up to 100 nm) aggregates filled with network cells (4-7 nm in size). The structural differences in the anionic, cationic, and amphiphilic hydrogels and the relationship between their structure and the ability of hydrogels to absorb moisture are shown. A relationship between the memory effect during cefazolin immobilization and the internal structure of hydrogels, depending on their composition and type of functional groups, is established.

• OSTI ID: 22054233
• Journal Information: Crystallography Reports, Vol. 56, Issue 7; Other Information: Copyright (c) 2011 Pleiades Publishing, Ltd.; Country of input: International Atomic Energy Agency (IAEA); ISSN 1063-7745
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY
RADIOCHEMISTRY AND NUCLEAR CHEMISTRY
75 CONDENSED MATTER PHYSICS
SUPERCONDUCTIVITY AND SUPERFLUIDITY
ACRYLIC ACID
COPOLYMERS
DRUGS
HYDROGELS
MEDICINE
METHACRYLATES
MONOMERS
NEUTRON DIFFRACTION
SMALL ANGLE SCATTERING