PathTracer Comprehensively Identifies Hypoxia-Induced Dormancy Adaptations in Mycobacterium tuberculosis

Banerjee, Ushashi; Chedere, Adithya; Padaki, Raksha; Mohan, Abhilash; Sambaturu, Narmada; Singh, Amit; Chandra, Nagasuma

doi:10.1021/acs.jcim.3c00845

PathTracer Comprehensively Identifies Hypoxia-Induced Dormancy Adaptations in Mycobacterium tuberculosis

Journal Article · Wed Sep 27 00:00:00 EDT 2023 · Journal of Chemical Information and Modeling

DOI:https://doi.org/10.1021/acs.jcim.3c00845· OSTI ID:2204207

Banerjee, Ushashi ^[1]; ^[1]; Padaki, Raksha ^[1]; Mohan, Abhilash ^[1]; Sambaturu, Narmada ^[2]; ^[1]; ^[1]

Indian Institute of Science, Bangalore (India)
Indian Institute of Science, Bangalore (India); Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Mining large-scale data to discover biologically relevant information remains a challenge despite the rapid development of bioinformatics tools. Here, we have developed a new tool, PathTracer, to identify biologically relevant information flows by mining genome-wide protein–protein interaction networks following integration of gene expression data. PathTracer successfully mines interactions between genes and traces the most perturbed paths of perceived activities under the conditions of the study. Here, we further demonstrated the utility of this tool by identifying adaptation mechanisms of hypoxia-induced dormancy in Mycobacterium tuberculosis (Mtb).

View Accepted Manuscript (DOE)

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: 89233218CNA000001

OSTI ID:: 2204207

Report Number(s):: LA-UR--23-25022

Journal Information:: Journal of Chemical Information and Modeling, Journal Name: Journal of Chemical Information and Modeling Journal Issue: 19 Vol. 63; ISSN 1549-9596

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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