Biomass RNA for the Controlled Synthesis of Degradable Networks by Radical Polymerization

Jeong, Jaepil; An, So Young; Hu, Xiaolei; Zhao, Yuqi; Yin, Rongguan; Szczepaniak, Grzegorz; Murata, Hironobu; Das, Subha R.; Matyjaszewski, Krzysztof

doi:10.1021/acsnano.3c08244

Title: Biomass RNA for the Controlled Synthesis of Degradable Networks by Radical Polymerization

Journal Article · Wed Oct 18 00:00:00 EDT 2023 · ACS Nano

DOI:https://doi.org/10.1021/acsnano.3c08244· OSTI ID:2202894

^[1]; An, So Young ^[2];

^[2];

^[3];

^[2]; Szczepaniak, Grzegorz ^[4]; Murata, Hironobu ^[2];

^[1];

^[2]

Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States, Center for Nucleic Acids Science & Technology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States
Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States
Department of Materials Science & Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States
Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States, University of Warsaw, Faculty of Chemistry, Pasteura 1, 02-093 Warsaw, Poland

Nucleic acids extracted from biomass have emerged as sustainable and environmentally friendly building blocks for the fabrication of multifunctional materials. Until recently, the fabrication of biomass nucleic acid-based structures has been facilitated through simple crosslinking of biomass nucleic acids, which limits the possibility of material properties engineering. This study presents an approach to convert biomass RNA into an acrylic crosslinker through acyl imidazole chemistry. The number of acrylic moieties on RNA was engineered by varying the acylation conditions. The resulting RNA crosslinker can undergo radical copolymerization with various acrylic monomers, thereby offering a versatile route for creating materials with tunable properties (e.g., stiffness and hydrophobic characteristics). Further, reversible-deactivation radical polymerization methods, such as atom transfer radical polymerization (ATRP) and reversible addition–fragmentation chain transfer (RAFT), were also explored as additional approaches to engineer the hydrogel properties. The study also demonstrated the metallization of the biomass RNA-based material, thereby offering potential applications in enhancing electrical conductivity. Overall, this research expands the opportunities in biomass-based biomaterial fabrication, which allows tailored properties for diverse applications.

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Research Organization:: Carnegie Mellon Univ., Pittsburgh, PA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC0018784

OSTI ID:: 2202894

Alternate ID(s):: OSTI ID: 2208751

Journal Information:: ACS Nano, Journal Name: ACS Nano Vol. 17 Journal Issue: 21; ISSN 1936-0851

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
59 BASIC BIOLOGICAL SCIENCES
RNA
hydrogel
biomass
acylation
ATRP
RAFT
free radical polymerization
copolymerization
genetics

Title: Biomass RNA for the Controlled Synthesis of Degradable Networks by Radical Polymerization

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