3'-deoxy-3'-[{sup 18}F]fluorothymidine PET Quantification of Bone Marrow Response to Radiation Dose

Journal Article · Tue Nov 01 00:00:00 EDT 2011 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2010.12.009· OSTI ID:21590472

Menda, Yusuf; Boles Ponto, Laura L ^[1]; Gross, Brandie; Buatti, John; Bayouth, John E ^[2]

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1. Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 (United States)
2. Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 (United States)

Purpose: The purpose of this study was to quantify the relationship of bone marrow response to radiation dose, using 3'-deoxy-3'-[{sup 18}F]fluorothymidine ([{sup 18}F]FLT)-labeled uptake quantified in positron-emission tomography (PET) scans. Methods and Materials: Pre- and post-Week 1 treatment [{sup 18}F]FLT PET images were registered to the CT images used to create the radiation treatment plan. Changes in [{sup 18}F]FLT uptake values were measured using profile data of standardized uptake values (SUVs) and doses along the vertebral bodies located at a field border where a range of radiation doses were present for 10 patients. Data from the profile measurements were grouped into 1 Gy dose bins from 1 to 9 Gy to compare SUV changes for all patients. Additionally, the maximum pretreatment, the post-Week 1 treatment, and the dose values located within the C6-T7 vertebrae that straddled the field edge were measured for all patients. Results: Both the profile and the individual vertebral data showed a strong correlation between SUV change and radiation dose. Relative differences in SUVs between bins >1 Gy and <7 Gy were statistically significant (p < 0.01, two-sample t test). The reduction in SUV was approximately linear until it reached a reduction threshold of 75%-80% in SUV for doses greater than 6 Gy/week for both the dose-binned data and the vertebral maximum SUVs. Conclusions: The change in SUV observed in head and neck cancer patients treated with chemoradiation shows the potential for using [{sup 18}F]FLT PET images for identifying active bone marrow and monitoring changes due to radiation dose. Additionally, the change in [{sup 18}F]FLT uptake observed in bone marrow for different weekly doses suggests potential dose thresholds for reducing bone marrow toxicity.

• OSTI ID: 21590472
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 81, Issue 3; Other Information: DOI: 10.1016/j.ijrobp.2010.12.009; PII: S0360-3016(10)03706-5; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BONE MARROW
CAT SCANNING
FLUORINE 18
HEAD
NECK
NEOPLASMS
ORGANIC FLUORINE COMPOUNDS
POSITRON COMPUTED TOMOGRAPHY
RADIATION DOSES
TOXICITY
VERTEBRAE
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DOSES
EMISSION COMPUTED TOMOGRAPHY
FLUORINE ISOTOPES
HEMATOPOIETIC SYSTEM
HOURS LIVING RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIGHT NUCLEI
NANOSECONDS LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
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SKELETON
TOMOGRAPHY