Model-Based Radiation Dose Correction for Yttrium-90 Microsphere Treatment of Liver Tumors With Central Necrosis

Journal Article · Tue Nov 01 00:00:00 EDT 2011 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2010.06.045· OSTI ID:21590422

Liu, Ching-Sheng ^[1]; Lin, Ko-Han ^[2]; Lee, Rheun-Chuan ^[3]; Tseng, Hsiou-Shan ^[3]; Wang, Ling-Wei; Huang, Pin-I; Chao, Liung-Sheau ^[4]; Chang, Cheng-Yen ^[3]; Yen, Sang-Hue ^[4]; Tung, Chuan-Jong ^[5]; Wang, Syh-Jen ^[1]; Oliver Wong, Ching-yee ^[6]; Liu, Ren-Shyan ^[1]

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1. National PET/Cyclotron Center, Taipei Veterans General Hospital, Taipei, Taiwan (China)
2. Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan (China)
3. Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan (China)
4. Cancer Therapy Center, Taipei Veterans General Hospital, Taipei, Taiwan (China)
5. Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan (China)
6. Department of Nuclear Medicine and PET/Cyclotron Center, Oakland University William Beaumont School of Medicine Hospital, Royal Oak, Michigan (United States)

Purpose: The objectives of this study were to model and calculate the absorbed fraction {phi} of energy emitted from yttrium-90 ({sup 90}Y) microsphere treatment of necrotic liver tumors. Methods and Materials: The tumor necrosis model was proposed for the calculation of {phi} over the spherical shell region. Two approaches, the semianalytic method and the probabilistic method, were adopted. In the former method, the range--energy relationship and the sampling of electron paths were applied to calculate the energy deposition within the target region, using the straight-ahead and continuous-slowing-down approximation (CSDA) method. In the latter method, the Monte Carlo PENELOPE code was used to verify results from the first method. Results: The fraction of energy, {phi}, absorbed from {sup 90}Y by 1-cm thickness of tumor shell from microsphere distribution by CSDA with complete beta spectrum was 0.832 {+-} 0.001 and 0.833 {+-} 0.001 for smaller (r{sub T} = 5 cm) and larger (r{sub T} = 10 cm) tumors (where r is the radii of the tumor [T] and necrosis [N]). The fraction absorbed depended mainly on the thickness of the tumor necrosis configuration, rather than on tumor necrosis size. The maximal absorbed fraction {phi} that occurred in tumors without central necrosis for each size of tumor was different: 0.950 {+-} 0.000, and 0.975 {+-} 0.000 for smaller (r{sub T} = 5 cm) and larger (r{sub T} = 10 cm) tumors, respectively (p < 0.0001). Conclusions: The tumor necrosis model was developed for dose calculation of {sup 90}Y microsphere treatment of hepatic tumors with central necrosis. With this model, important information is provided regarding the absorbed fraction applicable to clinical {sup 90}Y microsphere treatment.

• OSTI ID: 21590422
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 81, Issue 3; Other Information: DOI: 10.1016/j.ijrobp.2010.06.045; PII: S0360-3016(10)00897-7; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BIOMEDICAL RADIOGRAPHY
BLOOD VESSELS
LIVER
MICROSPHERES
MONTE CARLO METHOD
NECROSIS
NEOPLASMS
PROBABILISTIC ESTIMATION
RADIATION DOSES
RADIOTHERAPY
YTTRIUM 90
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CALCULATION METHODS
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DOSES
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIOISOTOPES
RADIOLOGY
THERAPY
YTTRIUM ISOTOPES