Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model

Journal Article · Thu Sep 01 00:00:00 EDT 2011 · Toxicology and Applied Pharmacology

OSTI ID:21587828

Junyan, Liu ^[1]; Hong, Qiu ^[2]; Morisseau, Christophe; Hwang, Sung Hee; Tsai, Hsing-Ju; Ulu, Arzu ^[1]; Chiamvimonvat, Nipavan ^[2]

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1. Department of Entomology and Cancer Center, University of California, Davis, CA 95616 (United States)
2. Division of Cardiovascular Medicine, University of California, Davis, CA 95616 (United States)

The increasing use of the antimicrobial triclocarban (TCC) in personal care products (PCPs) has resulted in concern regarding environmental pollution. TCC is a potent inhibitor of soluble epoxide hydrolase (sEH). Inhibitors of sEH (sEHIs) are anti-inflammatory, anti-hypertensive and cardio-protective in multiple animal models. However, the in vivo effects anticipated from a sEHI have not been reported for TCC. Here we demonstrated the anti-inflammatory effects in vivo of TCC in a murine model. TCC was employed in a lipopolysaccharide (LPS)-challenged murine model. Systolic blood pressure, plasma levels of several inflammatory cytokines and chemokine, and metabolomic profile of plasma oxylipins were determined. TCC significantly reversed LPS-induced morbid hypotension in a time-dependent manner. TCC significantly repressed the increased release of inflammatory cytokines and chemokine caused by LPS. Furthermore, TCC significantly shifted the oxylipin profile in vivo in a time-dependent manner towards resolution of inflammation as expected from a sEHI. These results demonstrated that at the doses used TCC is anti-inflammatory in the murine model. This study suggests that TCC may provide some benefits in humans in addition to its antimicrobial activities due to its potent inhibition of sEH. It may be a promising starting point for developing new low volume high value applications of TCC. However these biological effects also caution against the general over use of TCC in PCPs. - Graphical abstract: Display Omitted Research Highlights: > Anti-microbial triclocarban (TCC) is anti-inflammatory in a murine model. > TCC significantly shifted the oxylipin profile in vivo as expected from a sEHI. > TCC significantly reversed LPS-induced morbid hypotension in a time-dependent manner. > TCC significantly repressed LPS-induced increased release of inflammatory cytokines.

• OSTI ID: 21587828
• Journal Information: Toxicology and Applied Pharmacology, Vol. 255, Issue 2; Other Information: DOI: 10.1016/j.taap.2011.06.017; PII: S0041-008X(11)00239-0; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0041-008X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
BENZOIC ACID
BLOOD PRESSURE
DODECANOIC ACID
EPOXIDES
HYPOTENSION
IN VIVO
INFLAMMATION
INHIBITION
INTERFERON
LIQUID COLUMN CHROMATOGRAPHY
MASS SPECTROSCOPY
MICE
PLASMA
TIME DEPENDENCE
UREA
AMIDES
ANIMALS
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACIDS
CHROMATOGRAPHY
GROWTH FACTORS
LYMPHOKINES
MAMMALS
MITOGENS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PROTEINS
RODENTS
SEPARATION PROCESSES
SPECTROSCOPY
SYMPTOMS
VERTEBRATES