A possible mechanism for 2,2',4,4',5,5'-hexachlorobiphenyl-mediated decrease in serum thyroxine level in mice

Journal Article · Fri Jul 01 00:00:00 EDT 2011 · Toxicology and Applied Pharmacology

DOI:https://doi.org/10.1016/j.taap.2011.04.020· OSTI ID:21587773

Kato, Yoshihisa ^[1]; Onishi, Mao ^[2]; Haraguchi, Koichi ^[3]; Ikushiro, Shinichi ^[4]; Ohta, Chiho; Koga, Nobuyuki ^[5]; Endo, Tetsuya ^[6]; Yamada, Shizuo; Degawa, Masakuni ^[2]

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1. Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa 769-2193 (Japan)
2. School of Pharmaceutical Sciences and Global Center of Excellence Program, University of Shizuoka, Shizuoka 422-8526 (Japan)
3. Daiichi College of Pharmaceutical Sciences, Fukuoka 815-8511 (Japan)
4. Faculty of Engineering, Toyama Prefectural University, Toyama 939-0398 (Japan)
5. Faculty of Nutritional Sciences, Nakamura Gakuen University, Fukuoka 814-0198 (Japan)
6. Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido, Hokkaido 061-0293 (Japan)

Serum total thyroxine (T{sub 4}) level was markedly decreased, without significant increases in the levels of hepatic T{sub 4}-UDP-glucuronosyltransferase (T{sub 4}-UGT) and serum thyroid-stimulating hormone, 3 days after treatment with 2,2',4,4',5,5'-hexachlorobiphenyl (CB153) (100 mg/kg, ip) in both 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-sensitive C57BL/6 and TCDD-resistant DBA/2 mice. Likewise, in either strain of mice, no CB153-mediated changes in the binding levels of [{sup 125}I]T{sub 4} to serum proteins, such as transthyretin, albumin, and thyroxine binding globulin, were observed, while in CB153-pretreated C57BL/6 mice, but not in CB153-pretreated DBA/2 mice, the levels of biliary [{sup 125}I]T{sub 4} and [{sup 125}I]T{sub 4}-glucuronide at 90-120 min after injection of [{sup 125}I]T{sub 4} slightly increased, as compared with those in the corresponding control mice. Concerning tissue distribution of [{sup 125}I]T{sub 4}, liver-selective increases in the [{sup 125}I]T{sub 4} accumulation by CB153-pretreatment were observed in both C57BL/6 and DBA/2 mice, and the hepatic levels of [{sup 125}I]T{sub 4} in the C57BL/6 and DBA/2 mice became more than 44% and 34% of the [{sup 125}I]T{sub 4} dosed, respectively. The present findings indicated that the CB153-mediated decreases in the level of serum total T{sub 4} in C57BL/6 and DBA/2 mice occur mainly through an increase in the accumulation of T{sub 4} in the liver.

• OSTI ID: 21587773
• Journal Information: Toxicology and Applied Pharmacology, Journal Name: Toxicology and Applied Pharmacology Journal Issue: 1 Vol. 254; ISSN TXAPA9; ISSN 0041-008X
• Country of Publication: United States
• Language: English

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60 APPLIED LIFE SCIENCES
ALBUMINS
AMINO ACIDS
ANIMALS
AROMATICS
BETA DECAY RADIOISOTOPES
BODY
BUILDUP
CARBOXYLIC ACIDS
CHLORINATED AROMATIC HYDROCARBONS
CHROMATOGRAPHY
CONTROL
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
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ELECTRON CAPTURE RADIOISOTOPES
GLANDS
GLOBULINS
HALOGENATED AROMATIC HYDROCARBONS
HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
HORMONES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE 125
IODINE ISOTOPES
ISOTOPES
LIQUID COLUMN CHROMATOGRAPHY
LIVER
MAMMALS
MICE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
POLYCHLORINATED BIPHENYLS
PROTEINS
RADIOISOTOPES
RODENTS
SEPARATION PROCESSES
THYROID HORMONES
THYROXINE
TISSUE DISTRIBUTION
TRIIODOTHYRONINE
TSH
VERTEBRATES