The Evolving Role of Radiation Therapy in the Management of Malignant Melanoma

Journal Article · Fri Jul 01 00:00:00 EDT 2011 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2010.12.071· OSTI ID:21587570

Khan, Niloufer ^[1]; Almasan, Alex; Singh, Arun D; Macklis, Roger ^[2]

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1. Case Western Reserve University School of Medicine, Cleveland, OH (United States)
2. Taussig Cancer Institute, Lerner College of Medicine and Cole Eye Institute, Cleveland Clinic, Cleveland, OH (United States)

The incidence of melanoma is rising in the United States, leading to an estimated 68,720 new diagnoses and 8,650 deaths annually. The natural history involves metastases to lymph nodes, lung, liver, brain, and often to other sites. Primary treatment for melanoma is surgical excision of the primary tumor and affected lymph nodes. The role of adjuvant or definitive radiation therapy in the treatment of melanoma remains controversial, because melanoma has traditionally been viewed as a prototypical radioresistant cancer. However, recent studies suggest that under certain clinical circumstances, there may be a significant role for radiation therapy in melanoma treatment. Stereotactic radiosurgery for brain metastases has shown effective local control. High dose per fraction radiation therapy has been associated with a lower rate of locoregional recurrence of sinonasal melanoma. Plaque brachytherapy has evolved into a promising alternative to enucleation at the expense of moderate reduction in visual acuity. Adjuvant radiation therapy following lymphadenectomy in node-positive melanoma prevents local and regional recurrence. The newer clinical data along with emerging radiobiological data indicate that radiotherapy is likely to play a greater role in melanoma management and should be considered as a treatment option.

• OSTI ID: 21587570
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 80, Issue 3; Other Information: DOI: 10.1016/j.ijrobp.2010.12.071; PII: S0360-3016(11)00211-2; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRACHYTHERAPY
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DIAGNOSIS
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LUNGS
LYMPH NODES
MELANOMAS
METASTASES
RADIATION DOSES
SURGERY
BODY
CARCINOMAS
CENTRAL NERVOUS SYSTEM
DIGESTIVE SYSTEM
DISEASES
DOSES
EPITHELIOMAS
GLANDS
LYMPHATIC SYSTEM
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
THERAPY