Predicting relative toxicity and interactions of divalent metal ions: Microtox{reg_sign} bioluminescence assay

Journal Article · Fri Mar 01 04:00:00 EST 1996 · Environmental Toxicology and Chemistry

DOI:https://doi.org/10.1002/etc.5620150308· OSTI ID:215598

Newman, M C; McCloskey, J T ^[1]

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1. Savannah River Ecology Lab., Aiken, SC (United States)

Both relative toxicity and interactions between paired metal ions were predicted with least-squares linear regression and various ion characteristics. Microtox{reg_sign} 15 min EC50s (expressed as free ion) for Ca(II), Cd(II), Cu(II), Hg(II), Mg(II), Mn(II), Ni(II), Pb(II), and Zn(II) were most effectively modeled with the constant for the first hydrolysis (K{sub H} for M{sup n+} + H{sub 2}O {yields} MOH{sup a{minus}1} + H{sup +}) although other ion characteristics were also significant in regression models. The {vert_bar}log K{sub H}{vert_bar} is correlated with metal ion affinity to intermediate ligands such as many biochemical functional groups with O donor atoms. Further, ordination of metals according to ion characteristics, e.g., {vert_bar}log K{sub H}{vert_bar} facilitated prediction of paired metal interactions. Pairing metals with strong tendencies to complex with intermediate or soft ligands such as those with O or S donor atoms resulted in strong interactions.

• Sponsoring Organization: USDOE
• OSTI ID: 215598
• Journal Information: Environmental Toxicology and Chemistry, Journal Name: Environmental Toxicology and Chemistry Journal Issue: 3 Vol. 15; ISSN 0730-7268; ISSN ETOCDK
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
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FORECASTING
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MAGNESIUM
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MERCURY
NICKEL
PHOTOSYNTHETIC BACTERIA
SENSITIVITY
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