Ion, X-Ray, UV And Neutron Microbeam Systems For Cell Irradiation

Journal Article · Wed Jun 01 00:00:00 EDT 2011 · AIP Conference Proceedings

DOI:https://doi.org/10.1063/1.3586118· OSTI ID:21519891

Bigelow, A W; Randers-Pehrson, G; Garty, G; Geard, C R; Xu, Y; Harken, A D; Johnson, G W; Brenner, D J ^[1]

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1. Center for Radiological Research, Columbia University, 630 West 168th Street, 11th floor, New York, NY 10032 (United States)

The array of microbeam cell-irradiation systems, available to users at the Radiological Research Accelerator Facility (RARAF), Center for Radiological Research, Columbia University, is expanding. The HVE 5MV Singletron particle accelerator at the facility provides particles to two focused ion microbeam lines: the sub-micron microbeam II and the permanent magnetic microbeam (PMM). Both the electrostatic quadrupole lenses on the microbeam II system and the magnetic quadrupole lenses on the PMM system are arranged as compound lenses consisting of two quadrupole triplets with 'Russian' symmetry. Also, the RARAF accelerator is a source for a proton-induced x-ray microbeam (undergoing testing) and is projected to supply protons to a neutron microbeam based on the {sup 7}Li(p,n){sup 7}Be nuclear reaction (under development). Leveraging from the multiphoton microscope technology integrated within the microbeam II endstation, a UV microspot irradiator - based on multiphoton excitation - is available for facility users. Highlights from radiation-biology demonstrations on single living mammalian cells are included in this review of microbeam systems for cell irradiation at RARAF.

• OSTI ID: 21519891
• Journal Information: AIP Conference Proceedings, Vol. 1336, Issue 1; Conference: CAARI 2010: 21. International Conference on the Application of Accelerators in Research and Industry, Fort Worth, TX (United States), 8-13 Aug 2010; Other Information: DOI: 10.1063/1.3586118; (c) 2011 American Institute of Physics; ISSN 0094-243X
• Country of Publication: United States
• Language: English

Related Subjects

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
ACCELERATOR FACILITIES
ANIMAL CELLS
BERYLLIUM 7
ELECTROSTATIC ACCELERATORS
EXCITATION
IONS
IRRADIATION
LITHIUM 7 TARGET
MICROSCOPES
MULTI-PHOTON PROCESSES
NEUTRON BEAMS
NEUTRON EMISSION
NEUTRONS
PROTON REACTIONS
SYMMETRY
X RADIATION
ACCELERATORS
ALKALINE EARTH ISOTOPES
BARYON REACTIONS
BARYONS
BEAMS
BERYLLIUM ISOTOPES
BETA DECAY RADIOISOTOPES
CHARGED PARTICLES
CHARGED-PARTICLE REACTIONS
DAYS LIVING RADIOISOTOPES
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTARY PARTICLES
EMISSION
ENERGY-LEVEL TRANSITIONS
EVEN-ODD NUCLEI
FERMIONS
HADRON REACTIONS
HADRONS
IONIZING RADIATIONS
ISOTOPES
LIGHT NUCLEI
NUCLEAR REACTIONS
NUCLEI
NUCLEON BEAMS
NUCLEON REACTIONS
NUCLEONS
PARTICLE BEAMS
RADIATIONS
RADIOISOTOPES
TARGETS