Patterns of Failure and Treatment-Related Toxicity in Advanced Cervical Cancer Patients Treated Using Extended Field Radiotherapy With Curative Intent

Journal Article · Wed Jun 01 04:00:00 EDT 2011 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2010.02.026· OSTI ID:21491767

Rajasooriyar, Chrishanthi ^[1]; Van Dyk, Sylvia; Bernshaw, David ^[2]; Kondalsamy-Chennakesavan, Srinivas ^[3]; Barkati, Maroie; Narayan, Kailash ^[2]

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1. Division of Oncology, Teaching Hospital, Batticaloa (Sri Lanka)
2. Division of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne (Australia)
3. Queensland Centre for Gynaecological Cancer, Royal Brisbane and Women's Hospital, Queensland, and School of Medicine, University of Queensland (Australia)

Purpose: The purpose of this study was to evaluate the patterns of failure and overall survival (OS) and disease-free survival (DFS) rates in cervical cancer patients who had metastatic disease in common iliac or para-aortic lymph nodes and were treated with curative intent, using extended field radiotherapy (EFRT). Methods and Materials: This was a retrospective study involving 39 patients treated from January 1996 to June 2007, using EFRT with concurrent chemotherapy and intracavitary brachytherapy. EFRT consisted of 45 Gy in 1.8-Gy fractions. Radiation to involved nodes was boosted to a total dose of 50.4 to 54 Gy. Primary tumor radiation was boosted to a dose of 80 Gy using brachytherapy. Results: Overall, 30 patients (77%) have relapsed. The 5-year OS rate was 26% (95% confidence interval [CI], 11-44). The 5-year DFS rate was 19.4% (95% CI, 8-35). Only 3 patients (7.5%) experienced treatment failure exclusively within the treatment field, and 2 patients underwent salvage treatment. Grade 3 to 4 acute bone marrow and gastrointestinal toxicities were observed in 10 (26%) and 7 (18%) patients, respectively. Conclusions: Concurrent chemotherapy and EFRT treatment was well tolerated. Most patients showed failure at multiple sites and outside the treatment field. Only 3/39 patients had failures exclusively within the treatment field, and 2 underwent salvage treatment.

• OSTI ID: 21491767
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 2 Vol. 80; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
BODY
BONE MARROW
BRACHYTHERAPY
CHEMOTHERAPY
DISEASES
FAILURES
HEMATOPOIETIC SYSTEM
LYMPH NODES
LYMPHATIC SYSTEM
MEDICINE
METASTASES
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
RADIOTHERAPY
THERAPY
TOXICITY
UROGENITAL SYSTEM DISEASES