Role of Adjuvant Radiotherapy in Granulosa Cell Tumors of the Ovary
- Juravinski Cancer Centre, Department of Gynecologic Oncology, Hamilton Health Sciences Centre and McMaster University, Hamilton, ON (Canada)
- Department of Gynecologic Oncology, Sheba Medical Centre, Tel-Aviv University, Tel-Aviv (Israel)
- Department of Gynecologic Oncology, Queens University, Belfast, Northern Ireland (United Kingdom)
- Department of Gynecologic Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, ON (Canada)
- Department of Pathology, St. Joseph's Health Centre, University of Toronto, Toronto, ON (Canada)
- Department of Biostatistics, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, ON (Canada)
- Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, ON (Canada)
Purpose: To review the role of adjuvant radiotherapy (RT) in the outcome and recurrence patterns of granulosa cell tumors (GCTs) of the ovary. Methods and Materials: The records of all patients with GCTs referred to the Princess Margaret Hospital University Health Network between 1961 and 2006 were retrospectively reviewed. The patient, tumor, and treatment factors were assessed by univariate and multivariate analyses using disease-free survival (DFS) as the endpoint. Results: A total of 103 patients with histologically confirmed GCTs were included in the present study. The mean duration of follow-up was 100 months (range, 1-399). Of the 103 patients, 31 received adjuvant RT. A total of 39 patients developed tumor recurrence. The tumor size, incidence of intraoperative rupture, and presence of concurrent endometrial cancer were not significant risk factors for DFS. The median DFS was 251 months for patients who underwent adjuvant RT compared with 112 months for patients who did not (p = .02). On multivariate analysis, adjuvant RT remained a significant prognostic factor for DFS (p = .004). Of the 103 patients, 12 had died and 44 were lost to follow-up. Conclusion: Ovarian GCTs can be indolent, with patients achieving long-term survival. In our series, adjuvant RT resulted in a significantly longer DFS. Ideally, randomized trials with long-term follow-up are needed to define the role of adjuvant RT for ovarian GCTs.
- OSTI ID:
- 21491632
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Vol. 79, Issue 3; Other Information: DOI: 10.1016/j.ijrobp.2009.12.005; PII: S0360-3016(09)03610-4; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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