Prognostic Cell Biological Markers in Cervical Cancer Patients Primarily Treated With (Chemo)radiation: A Systematic Review

Journal Article · Tue Feb 01 00:00:00 EST 2011 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/j.ijrobp.2010.09.043· OSTI ID:21491567

Noordhuis, Maartje G; Eijsink, Jasper J.H.; Roossink, Frank; Graeff, Pauline de ^[1]; Pras, Elisabeth ^[2]; Schuuring, Ed ^[3]; Wisman, G Bea A. ^[1]; Bock, Geertruida H. de ^[4]

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1. Department of Gynecologic Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)
2. Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)
3. Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)
4. Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)

The aim of this study was to systematically review the prognostic and predictive significance of cell biological markers in cervical cancer patients primarily treated with (chemo)radiation. A PubMed, Embase, and Cochrane literature search was performed. Studies describing a relation between a cell biological marker and survival in {>=}50 cervical cancer patients primarily treated with (chemo)radiation were selected. Study quality was assessed, and studies with a quality score of 4 or lower were excluded. Cell biological markers were clustered on biological function, and the prognostic and predictive significance of these markers was described. In total, 42 studies concerning 82 cell biological markers were included in this systematic review. In addition to cyclooxygenase-2 (COX-2) and serum squamous cell carcinoma antigen (SCC-ag) levels, markers associated with poor prognosis were involved in epidermal growth factor receptor (EGFR) signaling (EGFR and C-erbB-2) and in angiogenesis and hypoxia (carbonic anhydrase 9 and hypoxia-inducible factor-1{alpha}). Epidermal growth factor receptor and C-erbB-2 were also associated with poor response to (chemo)radiation. In conclusion, EGFR signaling is associated with poor prognosis and response to therapy in cervical cancer patients primarily treated with (chemo)radiation, whereas markers involved in angiogenesis and hypoxia, COX-2, and serum SCC-ag levels are associated with a poor prognosis. Therefore, targeting these pathways in combination with chemoradiation may improve survival in advanced-stage cervical cancer patients.

• OSTI ID: 21491567
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Vol. 79, Issue 2; Other Information: DOI: 10.1016/j.ijrobp.2010.09.043; PII: S0360-3016(10)03352-3; Copyright (c) 2011 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; ISSN 0360-3016
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ANGIOGENESIS
ANOXIA
ANTIGENS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MARKERS
CARBONIC ANHYDRASE
CARCINOMAS
COMBINED THERAPY
EPIDERMIS
GROWTH FACTORS
RECEPTORS
REVIEWS
UROGENITAL SYSTEM DISEASES
ANIMAL TISSUES
BODY
CARBON-OXYGEN LYASES
DISEASES
DOCUMENT TYPES
ENZYMES
EPITHELIUM
HYDRO-LYASES
LYASES
MEDICINE
MEMBRANE PROTEINS
MITOGENS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
SKIN
THERAPY