Spectrally resolved fluorescence diffuse tomography of biological tissues

Journal Article · Fri Aug 27 00:00:00 EDT 2010 · Quantum Electronics (Woodbury, N.Y.)

DOI:https://doi.org/10.1070/QE2010V040N06ABEH014278· OSTI ID:21471341

Kleshnin, M S; Turchin, I V ^[1]

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1. Institute of Applied Physics, Russian Academy of Sciences, Nizhnii Novgorod (Russian Federation)

Spectrally resolved fluorescence diffuse tomography (SFDT) is demonstrated to be an effective approach to the reconstruction of the fluorescent agent distribution in biological tissues. Analysis of the measured optical power spectrum enables more accurate fluorophore localisation in solving the inverse tomography problem, because the dispersion of the optical parameters of the imaging subject leads to characteristic changes in the shape of its fluorescence spectrum. The SFDT system built by us includes a common optical fibre output of light sources and a single fibre input of the detector in an on-axis configuration, and an electromechanical scanner. The system enables studies of laboratory animals having tumours labelled with various fluorescent agents (fluorescent proteins, quantum dots and others). The first in vivo experiments have demonstrated the feasibility of tumour detection and localisation in laboratory animals by SFDT. (optical tomography)

• OSTI ID: 21471341
• Journal Information: Quantum Electronics (Woodbury, N.Y.), Vol. 40, Issue 6; Other Information: DOI: 10.1070/QE2010v040n06ABEH014278; ISSN 1063-7818
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
DISPERSIONS
FLUORESCENCE
FLUORESCENCE SPECTROSCOPY
IN VIVO
LABORATORY ANIMALS
LIGHT SOURCES
NEOPLASMS
OPTICAL FIBERS
PROTEINS
QUANTUM DOTS
SPECTRA
TOMOGRAPHY
ANIMALS
BODY
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION
EMISSION SPECTROSCOPY
FIBERS
LUMINESCENCE
NANOSTRUCTURES
ORGANIC COMPOUNDS
PHOTON EMISSION
RADIATION SOURCES
SPECTROSCOPY