Structural rearrangements in the aqueous phase of cell suspensions and protein solutions induced by a light-oxygen effect

Journal Article · Fri Feb 28 00:00:00 EST 2003 · Quantum Electronics (Woodbury, N.Y.)

DOI:https://doi.org/10.1070/QE2003V033N02ABEH002376· OSTI ID:21470265

Zakharov, S D; Nguen, K T; Panasenko, N A; Perov, S N; Timofeev, Yu P ^[1]; Ivanov, Andrei V ^[2]; Wolf, E B; Skopinov, S A ^[3]; Danilov, V P; Murina, T M; Novikov, E G ^[4]

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1. P.N. Lebedev Physics Institute, Russian Academy of Sciences, Moscow (Russian Federation)
2. N.N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow (Russian Federation)
3. Urals State Technical University, Ekaterinburg (Russian Federation)
4. A.M. Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow (Russian Federation)

Temperature-dependent transient processes initiated by a direct photogeneration of singlet oxygen in suspensions of human erythrocytes and solutions of serum albumin are studied. The processes appear as anomalous jumps in the temperature dependences of the deformability coefficient of erythrocytes and the refractive index of the extracellular medium and protein solution. In the temperature regions of anomalous jumps, cells and proteins transfer to a metastable state of a lower activity, but they can be isothermally photoreactivated. Simultaneously, a reversible rearrangement of the aqueous phase occurs near the cell and protein surfaces, accompanied by the formation of an extended corona (hydrogel). The transient processes are interpreted as phase transitions in the membrane of erythrocytes and conformation transitions in proteins. The interaction between erythrocytes and albumin via hydrogel is discovered (hydro-conformational interaction). A qualitative physical model of the early stages of the light-oxygen effect is proposed, in which collective magnetic interactions between the electron spins of oxygen molecules and the nuclear magnetic moments of protons in H{sub 2}O molecules play a dominant role. (special issue devoted to the 80th anniversary of academician n g basov's birth)

• OSTI ID: 21470265
• Journal Information: Quantum Electronics (Woodbury, N.Y.), Vol. 33, Issue 2; Other Information: DOI: 10.1070/QE2003v033n02ABEH002376; ISSN 1063-7818
• Country of Publication: United States
• Language: English

Related Subjects

75 CONDENSED MATTER PHYSICS
SUPERCONDUCTIVITY AND SUPERFLUIDITY
74 ATOMIC AND MOLECULAR PHYSICS
ALBUMINS
ELECTRONS
ERYTHROCYTES
INTERACTIONS
MOLECULES
NUCLEAR MAGNETIC MOMENTS
OXYGEN
PHASE TRANSFORMATIONS
PHOTON ACTIVATION ANALYSIS
PROTONS
REFRACTIVE INDEX
SOLUTIONS
SPIN
SURFACES
SUSPENSIONS
TEMPERATURE DEPENDENCE
VISIBLE RADIATION
WATER
ACTIVATION ANALYSIS
ANGULAR MOMENTUM
BARYONS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMICAL ANALYSIS
DISPERSIONS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ELEMENTS
FERMIONS
HADRONS
HOMOGENEOUS MIXTURES
HYDROGEN COMPOUNDS
LEPTONS
MAGNETIC MOMENTS
MATERIALS
MIXTURES
NONDESTRUCTIVE ANALYSIS
NONMETALS
NUCLEAR PROPERTIES
NUCLEONS
OPTICAL PROPERTIES
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
PARTICLE PROPERTIES
PHYSICAL PROPERTIES
PROTEINS
RADIATIONS