Optical coherent tomography measurements of the diffusion rate of water and drugs in an isolated and whole cornea
- University of Houston, Houston, Texas (United States)
The passive diffusion of drugs through the epithelial surfaces of an eye (the most widespread method for medical treatment of various diseases) is considered. The permeability of water and drugs through rabbit cornea was measured in the isolated cornea (separate from an eye) and in the whole cornea. The permeability coefficients of water and dexamethasone were estimated by the method of optical coherence tomography (OCT). Because multiple photon scattering introduces noise and distortions to the OCT signal, measurements were performed at depths up to 500 {mu}m where most likely single scattering of light occurs in cornea. It is shown that the permeability coefficients in the isolated and whole cornea strongly differ from each other. For example, the water permeability in the isolated and whole cornea is (7.09{+-}0.12)x10{sup -5} and (1.71{+-}0.51)x10{sup -5} cm s{sup -1}, respectively. (special issue devoted to multiple radiation scattering in random media)
- OSTI ID:
- 21456919
- Journal Information:
- Quantum Electronics (Woodbury, N.Y.), Vol. 36, Issue 12; Other Information: DOI: 10.1070/QE2006v036n12ABEH013225; ISSN 1063-7818
- Country of Publication:
- United States
- Language:
- English
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CORNEA
DEXAMETHASONE
DIFFUSION
DRUGS
PERMEABILITY
PHOTONS
RABBITS
SCATTERING
SIGNALS
SURFACES
TOMOGRAPHY
VISIBLE RADIATION
WATER
ADRENAL HORMONES
ANIMALS
BODY
BOSONS
CORTICOSTEROIDS
DIAGNOSTIC TECHNIQUES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EYES
FACE
GLUCOCORTICOIDS
HEAD
HORMONES
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
KETONES
MAMMALS
MASSLESS PARTICLES
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PHYSICAL PROPERTIES
PREGNANES
RADIATIONS
SENSE ORGANS
STEROID HORMONES
STEROIDS
VERTEBRATES